Otenabant

Otenabant

Systematic (IUPAC) name
1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4- carboxamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	686344-29-6 Y
ATC code	None
UNII	J8211Y53EF N
KEGG	D09362 Y
ChEMBL	CHEMBL562668 N
Chemical data
Formula	C25H25Cl2N7O
Mol. mass	510.4
N(what is this?)  (verify)

Otenabant (CP-945,598) is a drug which acts as a potent and highly selective CB₁ antagonist.^[1] It was developed by Pfizer for the treatment of obesity,^[2] but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant.^[3]

See also

• Discovery and development of Cannabinoid Receptor 1 Antagonists

References

1. ^ Kim, M.; Yun, H.; Kwak, H.; Kim, J.; Lee, J. (2008), "Design, chemical synthesis, and biological evaluation of novel triazolyl analogues of taranabant (MK-0364), a cannabinoid-1 receptor inverse agonist", Tetrahedron 64 (48): 10802–10809, doi:10.1016/j.tet.2008.09.057, http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6THR-4TJ1HGJ-9-2&_cdi=5289&_user=713789&_orig=search&_coverDate=11%2F24%2F2008&_sk=999359951&view=c&wchp=dGLbVzb-zSkWA&md5=2e8fe6fab24adb1087bd17bbcd3544a7&ie=/sdarticle.pdf 
2. ^ Woods SC. The endocannabinoid system: novel pathway for cardiometabolic Risk-factor reduction. Journal of the American Academy of Physician Assistants. 2007 Nov;Suppl Endocannabinoid:7-10. PMID 18047036
3. ^ http://www.pfizer.com

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