AM-855

Drugbox
IUPAC_name = (4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho [3,2-c] isochromen-12-ol


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PubChem= 10091328
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C=26 | H=38 | O=2
molecular_weight = 382.577 g/mol
smiles = Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC
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AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a Ki of 22.3nM at CB₁ and 58.6nM at CB₂. [Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A. Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol. "Bioorganic and Medicinal Chemistry Letters". 1999 Aug 2;9(15):2119-24. PMID 10465529]

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