Nonabine

Nonabine
Nonabine
Systematic (IUPAC) name
7-(1,2-dimethylheptyl)-2,2-dimethyl-4-(4-pyridinyl)-2H-1-benzopyran-5-ol
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 16985-03-8
ATC code None
UNII 77DUK856J7 YesY
Chemical data
Formula C25H33NO2 
Mol. mass 379.534 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Nonabine (BRL-4664) is a drug which is a cannabinoid derivative, which was developed for the prevention of nausea and vomiting associated with cancer chemotherapy.[1] It has strong antiemetic effects equivalent to those of chlorpromazine, and also produces some mild sedative effects, along with dry mouth and EEG changes typical of cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.[2][3]


References

  1. ^ Staquet M, Bron D, Rozencweig M, Kenis Y. Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting. Journal of Clinical Pharmacology. 1981 Aug-Sep;21(8-9 Suppl):60S-63S. PMID 7197692
  2. ^ Archer CB, Amlot PL, Trounce JR. Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine. British Medical Journal (Clinical Research Edition). 1983 Jan 29;286(6362):350-1. PMID 6402096
  3. ^ McClelland GR, Sutton JA. Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects. Psychopharmacology (Berlin). 1985;85(3):306-8. PMID 2860687
v · d · eAntiemetics (A04)
5-HT3 Antagonists
CB1 Agonists (Cannabinoids)
Dronabinol • Nabilone • Nonabine
D2/D3 Antagonists
H1 Antagonists (Antihistamines)
mACh Antagonists (Anticholinergics)
NK1 Antagonists
Aprepitant • Casopitant • Ezlopitant • Fosaprepitant • Maropitant • Vestipitant
Others

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte


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