- HU-308
Drugbox
IUPAC_name = [(1R,2R,5R)-2- [2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl] -7,7-dimethyl-4-bicyclo [3.1.1] hept-3-enyl] methanol
width = 260
CAS_number = 256934-39-1
ATC_prefix =
ATC_suffix =
PubChem = 5311172
DrugBank =
C=27|H=43|O=2
molecular_weight = 414.621 g/mol
smiles = CCCCCCC(C)(C)C1=CC(=C(C(=C1)OC)C2C=C(C3CC2C3(C)C)CO)OC
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status = Legal
routes_of_administration =HU-308 is a drug which acts as a
cannabinoid agonist . It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1. [Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M, Pertwee RG, Ross RA, Mechoulam R, Fride E. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. "Proceedings of the National Academy of Sciences USA". 1999 Dec 7;96(25):14228-33. PMID 10588688] The synthesis and characterization took place in the laboratory of Prof. Mechoulam at theHebrew University of Jerusalem in the late 1990s. It hasanalgesic effects, [LaBuda CJ, Koblish M, Little PJ. Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. "European Journal of Pharmacology". 2005 Dec 19;527(1-3):172-4. PMID 16316653] promotes proliferation ofneural stem cells , [Palazuelos J, Aguado T, Egia A, Mechoulam R, Guzmán M, Galve-Roperh I. Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. "Federation of American Societies for Experimental Biology Journal". 2006 Nov;20(13):2405-7. PMID 17015409] and protects both liver and blood vessel tissues against oxidative stress via inhibition ofTNF-α . [Rajesh M, Pan H, Mukhopadhyay P, Bátkai S, Osei-Hyiaman D, Haskó G, Liaudet L, Gao B, Pacher P. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. "Journal of Leukocyte Biology". 2007 Dec;82(6):1382-9. PMID 17652447] [Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Huffman JW, Csiszar A, Ungvari Z, Mackie K, Chatterjee S, Pacher P. CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. "American Journal of Physiology. Heart and Circulatory Physiology". 2007 Oct;293(4):H2210-8. PMID 17660390]References
Wikimedia Foundation. 2010.