- O-2545
-
O-2545 Systematic (IUPAC) name (6aR,10aR)-6a,7,10,10a-Tetrahydro-3-[5-(1H-imidazol-1-yl)-1,1-dimethylpentyl]-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol Clinical data Pregnancy cat. ? Legal status Unscheduled Identifiers CAS number 874745-42-3 ATC code ? Chemical data Formula C26H36N2O2 Mol. mass 408.575 g/mol SMILES eMolecules & PubChem (what is this?) (verify) O-2545 is an analgesic cannabinoid derivative created by Organix Inc. for use in scientific research. Unlike most cannabinoids discovered to date, it is water soluble, which gives it considerable advantages over many related cannabinoids. It has high affinity for both CB1 and CB2 receptors, with Ki values of 1.5nM at CB1 and 0.32nM at CB2.[1]
See also
- O-2372
- Tropoxane
References
- ^ Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, Cottney J, Adams J, Baker J, Hill D, Saha B, Zerkowski J, Mahadevan A, Razdan RK. Pharmacological characterization of novel water-soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics. 2006 Sep;318(3):1230-9. PMID 16757541
Cannabinoids Plant cannabinoids Cannabinoid metabolites 8,11-DiOH-THC · 11-COOH-THC · 11-OH-THC
Endogenous cannabinoids Arachidonoyl ethanolamide (Anandamide or AEA) · 2-Arachidonoylglycerol (2-AG) · 2-Arachidonyl glyceryl ether (noladin ether) · Virodhamine · Palmitoylethanolamide (PEA) · N-Arachidonoyl dopamine (NADA) · Oleamide · RVD-Hpα
Synthetic cannabinoid
receptor agonistsClassical cannabinoids
(Dibenzopyrans)A-40174 · A-41988 · A-42574 · Ajulemic acid · AM-087 · AM-411 · AM-855 · AM-905 · AM-906 · AM-919 · AM-926 · AM-938 · AM-4030 · AMG-1 · AMG-3 · AMG-36 · AMG-41 · Dexanabinol (HU-211) · DMHP · Dronabinol · HHC · HU-210 · JWH-051 · JWH-133 · JWH-139 · JWH-161 · JWH-229 · JWH-359 · KM-233 · L-759,633 · L-759,656 · Levonantradol (CP 50,5561) · Nabazenil · Nabidrox (Canbisol) · Nabilone · Nabitan · Naboctate · O-581 · O-774 · O-806 · O-823 · O-1057 · O-1125 · O-1238 · O-2365 · O-2372 · O-2373 · O-2383 · O-2426 · O-2484 · O-2545 · O-2694 · O-2715 · O-2716 · O-3223 · O-3226 · Parahexyl · Perrottetinene · Pirnabine · THC-O-acetate · THC-O-phosphate
Nonclassical cannabinoidsBenzoylindoles1-Butyl-3-(2-methoxybenzoyl)indole · 1-Butyl-3-(4-methoxybenzoyl)indole · 1-Pentyl-3-(2-methoxybenzoyl)indole · AM-630 · AM-679 · AM-694 · AM-1241 · AM-2233 · GW-405,833 (L-768,242) · Pravadoline · RCS-4 · WIN 54,461
NaphthoylindolesNaphthylmethylindolesJWH-175 · JWH-184 · JWH-185 · JWH-192 · JWH-194 · JWH-195 · JWH-196 · JWH-197 · JWH-199
PhenylacetylindolesCannabipiperidiethanone · JWH-167 · JWH-203 · JWH-249 · JWH-250 · JWH-251 · JWH-302 · RCS-8
NaphthoylpyrrolesEicosanoidsAM-883 · Arachidonyl-2'-chloroethylamide (ACEA) · Arachidonylcyclopropylamide (ACPA) · Methanandamide (AM-356) · O-585 · O-689 · O-1812 · O-1860 · O-1861
OthersA-796,260 · A-834,735 · A-836,339 · Abnormal cannabidiol · AB-001 · AM-1248 · AZ-11713908 · BAY 38-7271 · BAY 59-3074 · CB-13 · CB-86 · GW-842,166X · JWH-171 · JWH-176 · JTE 7-31 · Leelamine · MDA-19 · O-1918 · O-2220 · Org 28312 · Org 28611 · SER-601 · UR-12 · VSN-16 · WIN 56,098
Allosteric modulators of
cannabinoid receptorsOrg 27569 · Org 27759 · Org 29647
Endocannabinoid
activity enhancersAM-404 · CAY-10401 · CAY-10429 · JZL184 · JZL195 · N-arachidonoyl-serotonin · O-1624 · PF-04457845 · PF-622 · PF-750 · PF-3845 · PHOP · URB-447 · URB-597 · URB-602 · URB-754 · Genistein · Arvanil · Olvanil · Kaempferol · Biochanin A
Cannabinoid receptor
antagonists and
inverse agonistsAM-251 · AM-281 · AM-630 · BML-190 · CAY-10508 · CB-25 · CB-52 · CB-86 · Drinabant · Hemopressin · Ibipinabant (SLV319) · JTE-907 · LY-320,135 · Taranabant (MK-0364) · MK-9470 · NESS-0327 · O-1184 · O-1248 · O-2050 · O-2654 · Otenabant · Rimonabant (SR141716) · SR144528 · Surinabant (SR147778) · TM-38837 · VCHSR
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