JWH-147

Drugbox
IUPAC_name = 1-hexyl-2-phenyl-4-(1-naphthoyl)pyrrole

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C=27|H=27|N=1|O=1
molecular_weight = 381.51 g/mol
smiles = c4ccccc4-c2cc(cn2CCCCCC)C(=O)c1cccc3c1cccc3
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legal_status = Legal
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JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₂ subtype, with a Ki of 11.0nM at CB₁ vs 7.1nM at CB₂. [Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB₁ and CB₂ receptors. "Bioorganic & Medicinal Chemistry Letters" 2006; 16:5432-5435.]

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