L-759,656

Drugbox
IUPAC_name = (6aR,10aR)-1-methoxy-6,6-dimethyl-9-methylidene-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo [c] chromene


width= 240
CAS_number=
ATC_prefix=
ATC_suffix=
PubChem= 5311216
DrugBank=
C=26 | H=40 | O=2
molecular_weight = 384.593 g/mol
smiles = CCCCCCC(C)(C)c(cc1OC)cc(OC2(C)C)c1C3C2CCC(=C)C3
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

L-759,656 is an analgesic drug which is a cannabinoid agonist. It is a highly selective agonist for the CB₂ receptor, with selectivity of 414x for CB₂ over CB₁, [Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. "British Journal of Pharmacology". 1999 Feb;126(3):665-72. PMID 10188977] although it is still not as selective as newer agents such as HU-308.

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂. [Huffman JW. The search for selective ligands for the CB2 receptor. "Current Pharmaceutical Design". 2000 Sep;6(13):1323-37. PMID 10903395] [Huffman JW. CB2 receptor ligands. "Mini Reviews in Medicinal Chemistry". 2005 Jul;5(7):641-9. PMID 16026310]

References