AM-906

Drugbox
IUPAC_name = (6aR,9R,10aR)-3- [(Z)-hept-1-enyl] -9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo [c] chromen-1-ol


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PubChem= 10089808
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C=23 | H=34 | O=3
molecular_weight = 358.513 g/mol
smiles = CCCCCC=Cc(cc1O)cc(OC(C)(C)C2CC3)c1C2CC3CO
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AM-906 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and selective agonist for the CB₁ cannabinoid receptor, with a Ki of 0.8nM at CB₁ vs 9.5nM at CB₂, a selectivity of almost 12x. [Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. "Journal of Medicinal Chemistry". 1998 Mar 26;41(7):1195-200. PMID 9544219]

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