URB754

chembox new
Name = URB754
ImageFile = URB754.svg
ImageSize = 250
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CASNo = 86672-58-4
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URB754 was originally reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase.cite journal |author=Makara JK, Mor M, Fegley D, Szabó SI, Kathuria S, Astarita G, Duranti A, Tontini A, Tarzia G, Rivara S, Freund TF, Piomelli D |title=Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus |journal=Nat. Neurosci. |volume=8 |issue=9 |pages=1139–41 |year=2005 |pmid=16116451 |doi=10.1038/nn1521] However, recent studies have shown that URB754 failed to inhibit recombinant MGL, and brain FAAH activity was also resistant to URB754. [cite journal |author=Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT |title=URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain |journal=Chem. Biol. |volume=13 |issue=8 |pages=811–4 |year=2006 |pmid=16931330 |doi=10.1016/j.chembiol.2006.07.008] Some controversy in the field remains regarding the use of this compound.

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