JWH-307

Drugbox
IUPAC_name = (5-(2-fluorophenyl)-1-pentylpyrrol-3-yl)-naphthalen-1-ylmethanone

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PubChem = 16049783
DrugBank =
C=26|H=24|F=1|N=1|O=1
molecular_weight = 385.472 g/mol
smiles = CCCCCN1C=C(C=C1C2=CC=CC=C2F)C(=O)C3=CC=CC4=CC=CC=C43
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legal_status = Legal
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JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₂ subtype, with a Ki of 7.7nM at CB₁ vs 3.3nM at CB₂. [Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB₁ and CB₂ receptors. "Bioorganic & Medicinal Chemistry Letters" 2006; 16:5432-5435.]

References