L-759,633

Drugbox
IUPAC_name = (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo [c] chromene


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PubChem= 5311215
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C=26 | H=40 | O=2
molecular_weight = 384.593 g/mol
smiles = CC=3CC1c2c(cc(cc2OC)C(C)(C)CCCCCC)OC(C)(C)C1CC=3
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L-759,633 is an analgesic drug which is a cannabinoid agonist. It is a fairly selective agonist for the CB₂ receptor, with selectivity of 163x for CB₂ over CB₁. [Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. "British Journal of Pharmacology". 1999 Feb;126(3):665-72. PMID 10188977]

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂. [Huffman JW. The search for selective ligands for the CB2 receptor. "Current Pharmaceutical Design". 2000 Sep;6(13):1323-37. PMID 10903395] [Huffman JW. CB2 receptor ligands. "Mini Reviews in Medicinal Chemistry". 2005 Jul;5(7):641-9. PMID 16026310]

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