Dissociative

Dissociative
See dissociation for the dissociative state in psychology. For the Australian band, see The Dissociatives.

Dissociatives are a class of psychoactive drugs which are said to reduce or block signals to the conscious mind from other parts of the brain.[1] Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances.[2] Some, which are nonselective in action and affect the dopamine [3] and/or opioid[4] systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression[citation needed], analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.[citation needed]

Contents

Classes of dissociatives

NMDA receptor antagonists

Main article: NMDA receptor antagonist

κ-opioid receptor agonists

Main article: Opioid

Effects

The effects of dissociatives can include sensory dissociation, hallucinations, mania, catalepsy, analgesia and amnesia.[9][10][11] The characteristic features of dissociative anesthesia were described as catalepsy, amnesia and analgesia.[9] According to Pender (1972), "the state has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment."[12] Bonta (2004) described dissociative anaesthesia as "... a peculiar anaesthetic state in which marked sensory loss and analgesia as well as amnesia is not accompanied by actual loss of consciousness."[13] Both Pender (1970) and Johnstone et al. (1959) reported that patients under anesthesia due to either ketamine or phencyclidine were prone to purposeless movements and had hallucinations (or "dreams"[14]) during and after anesthesia. Some patients found the hallucinations euphoric while others found them disturbing.

At sub-anesthetic doses, dissociatives alter many of the same cognitive and perceptual processes affected by other hallucinogenic drugs such as mescaline, LSD, and psilocybin; hence they are also considered hallucinogenic, psychotomimetic, and psychedelic.[15][16][17][18] Perhaps the most significant subjective differences between dissociatives and the classical hallucinogens (such as LSD and mescaline) are the dissociative effects, including: depersonalization, the feeling of being unreal, disconnected from one's self, or unable to control one's actions; and derealization, the feeling that the outside world is unreal or that one is dreaming.[19]

See also

References

  1. ^ Tamminga, C. A.; Tanimoto, K.; Kuo, S.; Chase, T. N.; Contreras, P. C.; Rice, K. C.; Jackson, A. E.; O'Donohue, T. L. (1987). "PCP-induced alterations in cerebral glucose utilization in rat brain: Blockade by metaphit, a PCP-receptor-acylating agent". Synapse 1 (5): 497–504. doi:10.1002/syn.890010514. PMID 2850626. 
  2. ^ Snyder, Solomon H. (1980). "Phencyclidine". Nature 285 (5764): 355–6. doi:10.1038/285355a0. PMID 7189825. 
  3. ^ Giannini, AJ; Eighan, MS; Loiselle, RH; Giannini, MC (1984). "Comparison of haloperidol and chlorpromazine in the treatment of phencyclidine psychosis". Journal of clinical pharmacology 24 (4): 202–4. PMID 6725621. 
  4. ^ Giannini, A. James; Nageotte, Catherine; Loiselle, Robert H.; Malone, Donald A.; Price, William A. (1984). "Comparison of Chlorpromazine, Haloperidol and Pimozide in the Treatment of Phencyclidine Psychosis: Da-2 Receptor Specificity". Clinical Toxicology 22 (6): 573–9. doi:10.3109/15563658408992586. PMID 6535849. 
  5. ^ Giannini, A. James; Underwood, Ned A.; Condon, Maggie (2000). "Acute Ketamine Intoxication Treated by Haloperidol". American Journal of Therapeutics 7 (6): 389–91. doi:10.1097/00045391-200007060-00008. PMID 11304647. 
  6. ^ Giannini, A. James; Giannini, Matthew C.; Price, William A. (1984). "Antidotal Strategies in Phencyclidine Intoxication". The International Journal of Psychiatry in Medicine 14 (4): 315–21. doi:10.2190/KKAW-PWGF-W7RQ-23GN. 
  7. ^ Giannini, A. James; Price, William A.; Loiselle, Robert H.; Malone, Donald W. (1985). "Treatment of Phenylcyclohexylpyrrolidine (Php) Psychosis with Haloperidol". Clinical Toxicology 23 (2-3): 185–9. doi:10.3109/15563658508990627. PMID 4057312. 
  8. ^ Tarter, RE; Ammerman, RT; Ott, PJ (1998). Handbook of Sustance Abuse: Neurobaehavioral Pharmacology. NY: Plenum Press. p. 265. ISBN 0-306-45884-5. 
  9. ^ a b Pender, John W. (1970). "Dissociative Anesthesia". California Medicine 113 (5): 73. PMC 1501800. PMID 18730444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1501800. 
  10. ^ Johnstone, M.; Evans, V.; Baigel, S. (1959). "SERNYL (C1−395) IN CLINICAL ANAESTHESIA". BJA: British Journal of Anaesthesia 31: 433–9. doi:10.1093/bja/31.10.433. 
  11. ^ Oduntan, S. A.; Gool, R. Y. (1970). "Clinical trial of ketamine (ci-581): A preliminary report". Canadian Anaesthetists' Society Journal 17: 411–6. doi:10.1007/BF03004705. 
  12. ^ Pender, John W. (October 1972). "Dissociative Anesthesia". California Medicine 117 (4): 46–7. PMC 1518731. PMID 18730832. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1518731. 
  13. ^ Bonta, I (2004). "Schizophrenia, dissociative anaesthesia and near-death experience; three events meeting at the NMDA receptor". Medical Hypotheses 62 (1): 23–8. doi:10.1016/S0306-9877(03)00307-4. PMID 14729000. 
  14. ^ Virtue, RW; Alanis, JM; Mori, M; Lafargue, RT; Vogel, JH; Metcalf, DR (1967). "An anesthetic agent: 2-orthochlorophenyl, 2-methylamino cyclohexanone HCl (CI-581).". Anesthesiology 28 (5): 823–33. PMID 6035012. 
  15. ^ Mason, Oliver J.; Morgan, Celia J.M.; Stefanovic, Ana; Curran, H Valerie (2008). "The Psychotomimetic States Inventory (PSI): Measuring psychotic-type experiences from ketamine and cannabis". Schizophrenia Research 103 (1-3): 138–42. doi:10.1016/j.schres.2008.02.020. PMID 18387788. 
  16. ^ Lim, DK (2003). "Ketamine associated psychedelic effects and dependence.". Singapore medical journal 44 (1): 31–4. PMID 12762561. http://www.sma.org.sg/smj/4401/4401a5.pdf. 
  17. ^ Gouzoulis-Mayfrank, E.; Heekeren, K.; Neukirch, A.; Stoll, M.; Stock, C.; Obradovic, M.; Kovar, K.-A. (2005). "Psychological Effects of (S)-Ketamine and N,N-Dimethyltryptamine (DMT): A Double-Blind, Cross-Over Study in Healthy Volunteers". Pharmacopsychiatry 38 (6): 301–11. doi:10.1055/s-2005-916185. PMID 16342002. 
  18. ^ Krupitsky, EM; Grinenko, AY (1997). "Ketamine psychedelic therapy (KPT): a review of the results of ten years of research.". Journal of psychoactive drugs 29 (2): 165–83. PMID 9250944. http://www.eleusis.us/resource-center/references/kpt10yrs.php. 
  19. ^ Vollenweider, F; Geyer, MA (2001). "A systems model of altered consciousness: integrating natural and drug-induced psychoses". Brain Research Bulletin 56 (5): 495–507. doi:10.1016/S0361-9230(01)00646-3. PMID 11750795. 
v · d · ePharmacology: major drug groups
Gastrointestinal tract/metabolism (A)
Blood and blood forming organs (B)
Cardiovascular system (C)
Skin (D)
Genitourinary system (G)
Endocrine system (H)
Infections and infestations (J, P, QI)
Antimicrobials: Antibacterials (Antimycobacterials) • Antifungals • Antivirals • Antiparasitics (Antiprotozoals, Anthelmintics, Ectoparasiticides) • IVIG • Vaccines
Malignant disease (L01-L02)
Immune disease (L03-L04)
Muscles, bones, and joints (M)
Brain and nervous system (N)
Analgesics • Anesthetics (General, Local) • Anorectics • Anti-ADHD Agents • Antiaddictives • Anticonvulsants • Antidementia Agents • Antidepressants • Antimigraine Agents • Antiparkinson's Agents • Antipsychotics • Anxiolytics • Depressants • Entactogens • Entheogens • Euphoriants • Hallucinogens (Psychedelics, Dissociatives, Deliriants) • Hypnotics/Sedatives • Mood Stabilizers • Neuroprotectives • Nootropics • Neurotoxins • Orexigenics • Serenics • Stimulants • Wakefulness-Promoting Agents
Respiratory system (R)
Sensory organs (S)
Other ATC (V)
v · d · eHallucinogens
Psychedelics
5-HT2AR agonists
Dissociatives
NMDAR antagonists
Deliriants
mAChR antagonists
Miscellaneous
Cannabinoids
CB1R agonists
Others
v · d · eDepressants
Antihistamines
H1R inverse agonists
Others
Antipsychotics
Mixed MOA
Typicals
Atypicals
Channel Blockers
Dissociatives
NMDAR Antagonists
Others
Dexoxadrol • Dizocilpine (MK-801) • Etoxadrol • Nitrous Oxide • Selfotel • Xenon ...
GABAergics
1,4-BD • Aceburic Acid • Gabaculine • GBL • GABA • GABOB • GHB • GHV • GVL • Isovaleramide • Isovaleric Acid • Phenibut • Picamilon • Tiagabine • Valeric Acid • Valerenic Acid • Valnoctamide • Valproic Acid (Sodium Valproate / Valproate Semisodium) • Valpromide • Vigabatrin
Alfaxalone • Allopregnanolone • Ganaxolone • Tetrahydrodeoxycorticosterone ...
Others
Glycinergics
Narcotics
MOR Agonists
Sympatholytics
α/β-AR Modulators
Others
Miscellaneous

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Dissociative — Dis*so ci*a*tive, a. Tending or leading to dissociation. [1913 Webster] …   The Collaborative International Dictionary of English

  • dissociative — ● dissociatif, dissociative adjectif Relatif à la dissociation. ● dissociatif, dissociative (expressions) adjectif Psychose dissociative, synonyme de schizophrénie. ● dissociatif, dissociative (synonymes) adjectif Relatif à …   Encyclopédie Universelle

  • dissociative —    The term dissociative comes from the Latin words dis (apart, away from each other) and associare (to gather, to unite). It translates loosely as a substance capable of evoking a loosening of associations . The term dissociative is used to… …   Dictionary of Hallucinations

  • dissociative — 1. adjective a) removing or separating from some association It was a lonely, dissociative time in my life, when I stayed holed up in my apartment for weeks on end. b) causing dissociation The dissociative techniques separated ammonium chloride… …   Wiktionary

  • dissociative — dis·so·cia·tive ( )dis ō s(h)ē .āt iv, shət iv adj of, relating to, or tending to produce dissociation <a dissociative chemical reaction> <hypnosis theoretically induces a dissociative state in the subject so that he or she is not aware… …   Medical dictionary

  • dissociative — /dɪˈsoʊʃətɪv/ (say di sohshuhtiv), / ˈsoʊsiətɪv/ (say sohseeuhtiv) adjective 1. of or relating to dissociation: *Hooked up to a pokie machine a gambler would almost become hypnotised and enter a dissociative state , the court heard. –aap news,… …  

  • dissociative — dissociate ► VERB 1) disconnect or separate. 2) (dissociate oneself from) declare that one is not connected with (someone or something). DERIVATIVES dissociation noun dissociative adjective. ORIGIN Latin dissociare separate …   English terms dictionary

  • Dissociative disorder — Classification and external resources ICD 10 F44 ICD 9 300.12 …   Wikipedia

  • Dissociative disorders — [Dissociative Disorders, ( [http://www.psychiatryonline.com/content.aspx?aID=9696 DSM IV, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition] )] are defined a conditions that involve disruptions or breakdowns of memory,… …   Wikipedia

  • Dissociative substitution — Dissociative reaction redirects here. For the disorder formerly known as dissociative reaction, see dissociative identity disorder. Dissociative substitution describes a pathway by which compounds interchange ligands. The term is typically… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”