Thebaine

Thebaine

chembox
ImageFile = Thebaine skeletal.svg
IUPACName = 6,7,8,14-tetradehydro-4,5a-epoxy- 3,6-dimethoxy-17-methylmorphinan
OtherNames = Paramorphine
Section1 = Chembox Identifiers
Abbreviations =
CASNo = 115-37-7
EINECS =
PubChem = 5321926
SMILES = CN1CCC23C4C(=CC=C2C1CC5 =C3C(=C(C=C5)OC)O4)OC
InChI =
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MeSHName = Thebaine
ChEBI = 9519
KEGG = C06173
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Section2 = Chembox Properties
Formula =
C =19 | H =21 | N =1 | O =3
MolarMass = 311.37 g/mol
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Section3 = Chembox Pharmacology
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Metabolism = "O"-demethylation Mikus G, Somogyi AA, Bochner F, Eichelbaum M. "Thebaine O-demethylation to oripavine: genetic differences between two rat strains." "Xenobiotica". 1991 Nov; 21(11):1501-9. PMID 1763524]
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Legal_US = Schedule II
Legal_UK = Class A
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Dependency_liability = Low WHO Advisory Group. [http://www.unodc.org/unodc/en/bulletin/bulletin_1980-01-01_1_page006.html "The dependence potential of thebaine."] "Bulletin on Narcotics". 1980; 32(1):45–54. Accessed October 5, 2007. PMID 6778542] Thebaine (paramorphine) is an opiate alkaloid. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects, causing strychnine-like convulsions at higher doses.Aceto MD, Harris LS, Abood ME, Rice KC. "Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine." "European Journal of Pharmacology". 1999 Jan 22;365(2-3):143-7. PMID 9988096] Thebaine is not used therapeutically, but can be converted industrially into a variety of compounds including oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine.

It is controlled under international law, is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdom and is controlled as a Schedule II of the Controlled Substances Act in America.

References


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Look at other dictionaries:

  • Thébaïne — Structure chimique de la thébaïne Général No CAS …   Wikipédia en Français

  • Thebaine — Thébaïne Thébaïne Structure chimique de la thébaïne Général No CAS …   Wikipédia en Français

  • thébaïne — [ tebain ] n. f. • 1837; de thébaïque ♦ Sc. Alcaloïde très toxique extrait de l opium. ● thébain, thébaine adjectif et nom (latin Thebanus) De Thèbes en Égypte, ou de Thèbes en Béotie. ⇒THÉBAÏNE, subst. fém. CHIM., PHARM. Alcaloïde très toxique… …   Encyclopédie Universelle

  • Thebaine — The*ba ine, n. [So called from a kind of Egyptian opium produced at Thebes.] (Chem.) A poisonous alkaloid, {C19H21NO3}, found in opium in small quantities, having a sharp, astringent taste, and a tetanic action resembling that of strychnine.… …   The Collaborative International Dictionary of English

  • thebaine — [thē′bə ēn΄, thi bā′in] n. [< L Thebae (< Gr Thēbai), Thebes + INE3: after an opium from Thebes] a colorless, crystalline, poisonous alkaloid, C19H21NO3, obtained from opium and used in medicine …   English World dictionary

  • thebaine — /ˈθibəin/ (say theebuheen), /θəˈbeɪin/ (say thuh bayeen), / aɪn/ (say uyn) noun a white crystalline poisonous alkaloid, C19H21NO3, present in opium in small quantities. {New Latin thēba(a) thebaine (from Greek Thebai Thebes) + ine2} …  

  • thebaine — ˈthēbəˌēn, thə̇ˈbāˌēn, āə̇n noun ( s) Etymology: New Latin thebaia Egyptian opium produced at Thebes (from Latin Thebae Thebes, from Greek Thēbai) + English ine : a poisonous crystalline alkaloid C19H21NO3 found in opium in small quantities,… …   Useful english dictionary

  • THÉBAINE (TRIADE) — THÉBAINE TRIADE Dans la religion égyptienne, on appelle triade thébaine le groupe divin que forme Amon de Karnak avec Mout et Khonsou. Amon avait généralement un double aspect: soit l’aspect humain ordinaire, soit l’aspect ithyphallique de Min,… …   Encyclopédie Universelle

  • thebaine — /thee beuh een , thi bay een, in/, n. Chem. a white, crystalline, slightly water soluble, poisonous alkaloid, C19H21NO3, present in opium in small quantities, but having a strychninelike rather than a narcotic effect. [1890 95; < NL theba(ia)… …   Universalium

  • thebaine — noun A poisonous alkaloid, paramorphine, obtained from opium; not used in medicine. See Also: morphine, codeine …   Wiktionary

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