Felbamate

Drugbox
IUPAC_name = "trideca-1,3,11-trien-5,7,9-triyne"


width=120
CAS_number=25451-15-4
ATC_prefix=N03
ATC_suffix=AX10
ATC_supplemental=
PubChem=3331
DrugBank=APRD00505
C=11 | H=14 | N=2 | O=4
molecular_weight = 238.24
bioavailability= > 90%
metabolism = Hepatic
elimination_half-life= 20-23 hours
excretion = ?
pregnancy_category = C (USA)
legal_status = Unscheduled
routes_of_administration= Oral

Felbamate (marketed under the brand name Felbatol by MedPointe) is an anticonvulsant drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.

Mechanism of action

As with most anticonvulsants, the precise mechanism is unknown. It has a weak inhibitory effect on GABA receptor binding sites.

It may also work as a NMDA receptor antagonist. [ [http://www.prous.com/molecules/default.asp?ID=131 Prous Science: Molecule of the Month January 2005] ]

Approval history

United States

*August 1993. Felbamate was approved for partial seizures with and without secondary generalization in adults and for Lennox-Gastaut Syndrome, a serious form of childhood epilepsy. Over the following year 150,000 people were started on felbamate therapy and a third of these became established.
*August 1 1994. It was urgently withdrawn [http://www.fda.gov/bbs/topics/NEWS/NEW00488.html] after 10 cases of aplastic anemia. A "Dear Doctor" letter was sent to 240,000 physicians.
*September 27 1994. Felbamate had a limited redemption in another "Dear Doctor" letter sent to 260,000 physicians. It was recommended that the drug remain available only for patients with severe epilepsy for whom the benefits outweigh the risks, and that changes be made to the product's labelling to reflect the newly recognized risk [http://www.fda.gov/bbs/topics/ANSWERS/ANS00605.html] . This redemption came with an additional warning since there had been 10 cases acute liver failure (4 of which were fatal). At this point, 10,000 to 12,000 people remained on the drug.

United Kingdom

*The drug is only available on a limited named-patient basis.

Indications and usage

*Adults: Monotherapy or adjunctive therapy in the treatment of partial seizures, with and without generalization.
*Children: Adjunctive therapy in the treatment of partial and generalized seizures associated with Lennox-Gastaut syndrome.

Dosing

Felbamate is available in tablets (400 mg and 600 mg) and as a peach-coloured oral suspension (600 mg/5 mL).
*Adults (> 14 years): begin with 1,200 mg daily given every 6 to 8 hours
*Children (2 > 14 years): 15 to 45 mg per kg per day given every 6 to 8 hours

ide effects

Adverse reactions include decreased appetite, vomiting, insomnia, nausea, dizziness, somnolence, and headache. Many patients report increased alertness with the drug.Two rare but very serious effects include aplastic anemia and hepatic (liver) failure. The risk of aplastic anemia is between 1:3,600 and 1:5,000, of which 30% of cases are fatal. The risk of hepatic failure is between 1:24,000 to 1:34,000, of which 40% of cases are fatal.

Drug interactions

Felbamate interacts with other AEDs, the dose of which may be reduced in order to avoid adverse effects.

References

* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1944909&query_hl=3 Felbamate for partial seizures: results of a controlled clinical trial.] : Leppik IE, Dreifuss FE, Pledger GW, Graves NM, Santilli N, Drury I, Tsay JY, Jacobs MP, Bertram E, Cereghino JJ, et al.: [Abstract] . "Neurology". 1991 Nov;41(11):1785–9.
* [http://www.felbatol.com/pi.pdf Felbatol: Prescribing Information]
* [http://www.rxlist.com/cgi/generic3/felbamate.htm RxList: Felbamate] contains extensive information including the patient warning and a sample consent form.
* [http://www.neuro.wustl.edu/epilepsy/pediatric/articleFelbamate.html Hard Choices with Felbamate]
* [http://www.aafp.org/afp/980201ap/curry.html Newer Antiepileptic Drugs: Gabapentin, Lamotrigine, Felbamate, Topiramate and Fosphenytoin]

External links

* [http://www.medpointepharma.com/ MedPonte Pharmaceuticals]