Nalfurafine

Nalfurafine

Systematic (IUPAC) name
(2E)-N-[(5α,6β)-17-(cyclopropylmethyl)- 3,14-dihydroxy- 4,5-epoxymorphinan- 6-yl]- 3-(3-furyl)- N-methylacrylamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	intravenous
Identifiers
CAS number	152658-17-8
ATC code	V03AX02
PubChem	CID 6445230
IUPHAR ligand	1651
UNII	XC41AVD567 Y
Synonyms	TRK-820
Chemical data
Formula	C28H32N2O5
Mol. mass	476.564 g/mol
Y(what is this?)  (verify)

Nalfurafine (INN and USAN;^[1] also known as AC-820, TRK-820; trade name Remitch) is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in people undergoing hemodialysis.^[2]

As of January 2010^[update], it is also being investigated for the treatment of pruritus in patients with chronic liver disease.^[3]

References

1. ^ Statement on a Nonproprietary Name adopted by the USAN Council
2. ^ "AC-820". Acologix. 2009. http://www.acologix.com/pipeline_ac-820.html. 
3. ^ ClinicalTrials.gov NCT00638495 Phase II Study of TRK-820 Soft Capsules — Intractable Pruritus in Patients With Chronic Liver Disease

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