- U-50488
Drugbox
IUPAC_name = 2-(3,4-dichlorophenyl)-N-methyl-N- [(1R,2R)-2-pyrrolidin-1-ylcyclohexyl] acetamide
width = 200
CAS_number = 67198-13-4
smiles = CN( [C@@H] 1CCCC [C@H] 1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
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PubChem = 3036289
DrugBank =
C=19|H=26|Cl=2|N=2|O=1
molecular_weight = 369.329 g/mol
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routes_of_administration =U-50488 is a drug which acts as a highly selective κ-opioid
agonist , but without any μ-opioid antagonist effects. [Von Voigtlander PF, Lewis RA. U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists. "Progress in Neuropsychopharmacology and Biological Psychiatry". 1982;6(4-6):467-70. PMID 6298890] It hasanalgesic ,diuretic andantitussive effects, [Kamei J. Role of opioidergic and serotonergic mechanisms in cough and antitussives. "Pulmonary Pharmacology". 1996 Oct-Dec;9(5-6):349-56. PMID 9232674] and reverses the memory impairment produced byanticholinergic drugs. [Hiramatsu M, Kameyama T. Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models. "Methods and Findings in Experimental and Clinical Pharmacology". 1998 Sep;20(7):595-9. PMID 9819804] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds. [Szmuszkovicz J. U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990. "Progress in Drug Research". 1999;52:167-95. PMID 10396128] [Szmuszkovicz J. U-50,488 and the kappa receptor. Part II: 1991-1998. "Progress in Drug Research". 1999;53:1-51. PMID 10616295]References
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