Divaplon

Divaplon: Divaplon

Systematic (IUPAC) name

(6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 90808-12-1

ATC code None

PubChem CID 65822

UNII 4AOV43246G^Y

Chemical data

Formula C₁₇H₁₇N₃O₂

Mol. mass 295.336

SMILES eMolecules & PubChem

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Divaplon (RU-32698) is a nonbenzodiazepine, anxiolytic and anticonvulsant drug from the pyrazolopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABA_A receptor in the brain.^[1]^[2]^[3]

References

^ Feely, M; Boyland, P; Picardo, A; Cox, A; Gent, JP (1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European journal of pharmacology 164 (2): 377–80. doi:10.1016/0014-2999(89)90482-2. PMID 2759183.

^ Sanger, DJ; Joly, D; Perrault, G (1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology 121 (1): 104–8. doi:10.1007/BF02245596. PMID 8539334.

^ Pellón, R; Ruíz, A; Lamas, E; Rodríguez, C (2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural pharmacology 18 (1): 81–7. doi:10.1097/FBP.0b013e3280143212. PMID 17218801.

v · d · eAnxiolytics (N05B)

GABA_A PAMs

Benzodiazepine

Adinazolam • Alprazolam • Bretazenil • Bromazepam • Camazepam • Chlordiazepoxide • Clobazam • Clonazepam • Clorazepate • Clotiazepam • Cloxazolam • Diazepam • Ethyl Loflazepate • Etizolam • Fludiazepam • Halazepam • Imidazenil • Ketazolam • Lorazepam • Medazepam • Nordazepam • Oxazepam • Pinazepam • Prazepam

Carbamates

Emylcamate • Mebutamate • Meprobamate (Carisoprodol, Tybamate) • Phenprobamate • Procymate

Nonbenzodiazepines

Abecarnil • Adipiplon • Alpidem • CGS-8216 • CGS-9896 • CGS-13767 • CGS-20625 • Divaplon • ELB-139 • Fasiplon • GBLD-345 • Gedocarnil • L-838,417 • NS-2664 • NS-2710 • Ocinaplon • Pagoclone • Panadiplon • Pipequaline • RWJ-51204 • SB-205,384 • SL-651,498 • Taniplon • TP-003 • TP-13 • TPA-023 • Y-23684 • ZK-93423

Pyrazolopyridines

Cartazolate • Etazolate • ICI-190,622 • Tracazolate

Others

Chlormezanone • Ethanol (Alcohol) • Etifoxine • Kavalactones (Kava Kava) • Skullcap • Valerenic Acid (Valerian)

α₂δ VDCC Blockers
Gabapentin • Pregabalin

5-HT_1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane

H₁ Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine

CRH₁ Antagonists
Antalarmin • CP-154,526 • Pexacerfont • Pivagabine

NK₂ Antagonists
GR-159,897 • Saredutant

MCH₁ antagonists
ATC-0175 • SNAP-94847

mGluR₂_/₃ Agonists
Eglumegad

mGluR5 NAMs
Fenobam

TSPO agonists
DAA-1097 • DAA-1106 • Emapunil • FGIN-127 • FGIN-143

σ₁ agonists
Afobazole • Opipramol

Others
Benzoctamine • Carbetocin • Demoxytocin • Mephenoxalone • Mepiprazole • Oxanamide • Oxytocin • Promoxolane • Tofisopam • Trimetozine • WAY-267,464

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)

Categories:
Anxiolytics
Ketones
Ethers
Imidazopyrimidines

Divaplon

Systematic (IUPAC) name
(6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	90808-12-1
ATC code	None
PubChem	CID 65822
UNII	4AOV43246G^Y
Chemical data
Formula	C₁₇H₁₇N₃O₂
Mol. mass	295.336
SMILES	eMolecules & PubChem
Y(what is this?) (verify)

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