Benzoctamine

drugbox
IUPAC_name = "N"-methyl-9,10-ethanoanthracene-9(10"H")-methanamine

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CAS_number = 17243-09-9
ATC_prefix = N05
ATC_suffix = BD01
PubChem = 28425
DrugBank =
C=18|H=19|N=1
molecular_weight = 249.35 g/mol
bioavailability =
protein_bound =
metabolism = Hepatic
elimination_half-life = 2 to 3 hours
excretion = Renal
pregnancy_AU =
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routes_of_administration =IV, oral

Benzoctamine is a drug that possessess sedative and anxiolytic properties. It is different from most sedative drugs because in most clinical trials it does not produce respiratory depression, but actually stimulates the respiratory system. When co-administered with other drugs that cause respiratory depression, like morphine, it can cause increased respiratory depression. Peak effects are reached at about an hour, and effects wear off after about 2-3 hours. This drug is also used as a sedative in the hospital scene in patients who have respiratory failure.

It appears to reduce turnover of serotonin.cite journal |author=Lippmann W, Pugsley TA |title=Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain |journal=Br. J. Pharmacol. |volume=51 |issue=4 |pages=571–5 |year=1974 |month=August |pmid=4480288 |pmc=1778070 |doi= |url=]

Its effects can be variable. [ [http://bja.oxfordjournals.org/cgi/content/abstract/47/9/987 BENZOCTAMINE-A STUDY OF THE RESPIRATORY EFFECTS OF ORAL DOSES IN HUMAN VOLUNTEERS AND INTERACTIONS WITH MORPHINE IN MICE - UTTING and PLEUVRY 47 (9): 987 - British Journal of Anaesthesia ] ]

References