- CGS-9896
drugbox
IUPAC_name = 2-(4-chlorophenyl)-1H-pyrazolo [4,5-c] quinolin-3-one
width = 180
CAS_number = 77779-36-3
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PubChem = 108030
DrugBank =
C=16|H=10|Cl=1|N=3|O=1
molecular_weight = 295.7231 g/mol
smiles = C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
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routes_of_administration =CGS-9896 is an
anxiolytic drug used in scientific research. It has similar effects tobenzodiazepine drugs, but is structurally distinct and so is classed as anonbenzodiazepine anxiolytic. [Leidenheimer NJ, Schechter MD. Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex. "Pharmacology, Biochemistry and Behaviour". 1988 Oct;31(2):249-54. [http://www.ncbi.nlm.nih.gov/pubmed/2854261 PMID 2854261] ]CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects. [Bernasconi R, Marescaux C, Vergnes M, Klebs K, Klein M, Martin P, Portet C, Maitre L, Schmutz M. Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models. "Journal of Neural Transmission". 1988;71(1):11-27. [http://www.ncbi.nlm.nih.gov/pubmed/3343593 PMID 3343593] ] [Rump S, Raszewski W, Gidynska T, Galecka E. Effects of CGS 9896 in acute experimental intoxication with fluostigmine. "Archives of Toxicology". 1990;64(5):412-3. [http://www.ncbi.nlm.nih.gov/pubmed/2206111 PMID 2206111] ] It also increases appetite, [Chen SW, Davies MF, Loew GH. Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake. "Pharmacology, Biochemistry and Behaviour". 1995 Jun-Jul;51(2-3):499-503. [http://www.ncbi.nlm.nih.gov/pubmed/7667375 PMID 7667375] ] and reduces the development of gastrointestinal ulcers following chronic stress. [Najim RA, Karim KH. Effect of CGS 9896 on stress-induced gastric ulcer in rat. "Clinical and Experimental Pharmacology and Physiology". 1990 Feb;17(2):157-161. [http://www.ncbi.nlm.nih.gov/pubmed/2109664 PMID 2109664] ]
References
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