Systematic (IUPAC) name
9-bromo-6-pyridin-2-yl- 2,5-diazabicyclo [5.4.0]undeca- 5,8,10,12-tetraen- 3-one
Clinical data
Trade names Lexotan, Lexotanil
AHFS/ Micromedex Detailed Consumer Information
Pregnancy cat. D (USA)
Legal status Schedule IV(US)
Routes Oral
Pharmacokinetic data
Bioavailability 84%
Metabolism Hepatic
Half-life 12-20 hours
Excretion Renal
CAS number 1812-30-2
ATC code N05BA08
PubChem CID 2441
DrugBank DB01558
ChemSpider 2347 YesY
UNII X015L14V0O YesY
KEGG D01245 YesY
Chemical data
Formula C14H10BrN3O 
Mol. mass 316.2
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Bromazepam (marketed under several brand names, including Lectopam, Lexotan, Lexilium, Lexaurin, Brazepam, Bromaze, and Lexotanil)[1] is a benzodiazepine derivative drug, patented by Roche in the 1963[2] and developed clinically in the 1970s.[3][4] It has mainly anxiolytic properties and at higher doses also sedative, hypnotic and skeletal muscle relaxant properties.[5]




All common side-effects of benzodiazepines have been noted. Consult the article under diazepam. Bromazepam 3 times 6 mg daily for 2 weeks taken alone impaired learning capacities significantly in humans in an experiment. In combination with alcohol the impairments of learning capacity became even more pronounced.[8] Impairments to memory functions are common with bromazepam and include a reduced working memory and reduced ability to process environmental information.[9][10][11] Impaired memory, visual information processing and sensory data and impaired psychomotor performance.[12][13][14] Deterioration of cognition including attention capacity and impaired co-ordinative skills.[15][16] Unsteadiness after taking bromazepam is however less pronounced than other benzodiazepines such as lorazepam.[17] Impaired reactive and attention performance, which may impair driving skills.[18]

Drowsiness and decrease in libido.[19][20] Occasionally benzodiazepines can induce extreme alterations in memory such as anterograde amnesia and amnesic automatism which may have medico-legal consequences. Such reactions usually only occur at the higher dose end of the prescribing spectrum.[21]

Very rarely dystonia can develop.[22]

Up to 30% treated on a long-term basis develop a form of dependence, i.e. these patients cannot stop the medication without experiencing physical and/or psychological benzodiazepine withdrawal symptoms.

Leukopenia and liver-damage of the cholostatic type with or without jaundice (icterus) have additionally been seen; the original manufacturer Roche recommends regular laboratory examinations to be performed routinely.

Ambulatory patients should be warned that Bromazepam may impair the ability to drive vehicles and to operate machinery. The impairment is worsened by consumption of alcohol, because both act as central nervous system depressants. During the course of therapy, tolerance to the sedative effect usually develops.

Tolerance, dependence and withdrawal

Bromazepam shares with other benzodiazepines the risk of abuse, misuse, psychological dependence and/or physical dependence.[23][24] A withdrawal study demonstrated both psychological dependence and physical dependence on bromazepam including marked rebound anxiety after 4 weeks chronic use. Those whose dose was gradually reduced experienced no withdrawal.[25]

Patients treated with bromazepam for generalised anxiety disorder were found to experience withdrawal symptoms such as a worsening of anxiety, as well as the development of physical withdrawal symptoms when abruptly withdrawn from bromazepam.[26] Abrupt or over rapid withdrawal from bromazepam after chronic use even at therapeutic prescribed doses may lead to a severe withdrawal syndrome including status epilepticus and a condition resembling delerium tremens.[27][28][29]

Animal studies have shown that chronic administration of diazepam or bromazepam causes a decrease in spontaneous locomotor activity and the turnover of noradrenaline and dopamine and serotonin, decreased activity of tyrosine hydroxylase and increased levels of the catecholamines. During withdrawal of bromazepam or diazepam a fall in tryptophan, 5-hydroxytryptamine levels occurs as part of the benzodiazepine withdrawal syndrome.[30]

Contraindications and special precautions

Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders.[31]

Special Populations


In 1987, a team of scientists led by Ochs reported that the elimination half-life, peak serum concentration, and serum free fraction are significantly elevated and the oral clearance and volume of distribution significantly lowered in elderly subjects.[32] The clinical consequence is that the elderly should be treated with lower doses than younger patients.


Bromazepam may affect driving and ability to operate machinery.[33]

Pregnancy and breast feeding

Bromazepam is pregnancy category D, a classification which means that bromazepam has been shown to cause harm to the unborn child. The Hoffman LaRoche product information leaflet warns against breast feeding while taking bromazepam. There has been at least one report of sudden infant death syndrome linked to breast feeding while consuming bromazepam.[34][35]


Cimetidine, fluvoxamine and propranolol causes a marked increase in the half-life of bromazepam leading to increased accumulation of bromazepam.[36][37][38]


Apo-Bromazepam 6 mg tablets (Canada)

Bromazepam is a "classical" benzodiazepine; other classical benzodiazepines include; diazepam, clonazepam, oxazepam, lorazepam, nitrazepam, flurazepam and clorazepate.[39] Its molecular structure is composed of a diazepine connected to a benzene ring and a pyridine ring, the benzene ring having a bromine atom attached to it.[40] It is a 1,4-benzodiazepine, which means that the nitrogens on the seven-sided diazepine ring are in the 1 and 4 positions.

Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced. Bromazepam is intermediate-short acting benzodiazepine and is lipophilic, is metabolised hepatically via oxidative pathways.[41] It does not possess any antidepressant or antipsychotic qualities.[42]

After night time administration of bromazepam a highly significant reduction of gastric acid secretion occurs during sleep followed by a highly significant rebound in gastric acid production the following day.[43]

Bromazepam alters electrical status of the brain causing an increased beta activity and a decrease in alpha activity in the EEG recordings.[44]


Bromazepam is reported to be metabolized by a hepatic enzyme belonging to the Cytochrome P450 family of enzymes. In 2003, a team led by Dr. Oda Manami at Oita Medical University reported that CYP3A4 was not the responsible enzyme, seeing as itraconazole, a known inhibitor of CYP3A4, did not effect its metabolism.[45] In 1995, J. van Harten at Solvay Duphar B.V.'s Department of Clinical Pharmacology in Weesp reported that fluvoxamine, which is a potent inhibitor of CYP1A2, a less potent CYP3A4 inhibitor, and a negligible inhibitor of CYP2D6, does inhibit its metabolism.[46]

The active metabolite of bromazepam is hydroxybromazepam, which has half-life approximately equal to bromazepam.[citation needed]


Bromazepam is commonly involved in drug overdoses.[47] Bromazepam is a drug sometimes used in suicide attempts.[48] A severe bromazepam benzodiazepine overdose may result in a alpha pattern coma type.[49] The toxicity of bromazepam in overdosage increases when combined with other CNS depressant drugs such as alcohol or sedative hypnotic drugs.[50] Bromazepam is the most common benzodiazepine involved in intentional overdoses in France.[51]

Drug misuse

Bromazepam has a similar misuse risk as other benzodiazepines such as diazepam.[52] In France car accidents involving psychotropic drugs in combination found benzodiazepines, mainly diazepam, nordiazepam, and bromazepam, to be the most common drug, almost twice that of the next most common drug cannabis.[53] Bromazepam has also been used for serious criminal offences including, robbery, homicide and to carry out sexual assaults.[54][55][56]

Legal Status

Bromazepam is a Schedule IV drug under the Convention on Psychotropic Substances.[57]

See also


  1. ^ "Benzodiazepine Names". Retrieved 2008-10-31. 
  2. ^ US patent 3100770, Rodney Ian Friar, "5-PYRIDYL-1,4-Benzodiazepine Compounds", published 1961-11-7, issued 1963-13-7 
  3. ^ "Bromazepam, a new anxiolytic: a comparative study with diazepam in general practice. Royal College of General Practitioners Medicines Surveillance Organisation". J R Coll Gen Pract 34 (266): 509–12. September 1984. PMC 1959670. PMID 6147412. 
  4. ^ Fontaine, R; Annable, L; Beaudry, P; Mercier, P; Chouinard, G (1985). "Efficacy and withdrawal of two potent benzodiazepines: bromazepam and lorazepam". Psychopharmacology bulletin 21 (1): 91–2. ISSN 0048-5764. PMID 2858908. 
  5. ^ "Bromazepam prescribing information (Roche)" (PDF). 
  6. ^ Guelfi JD, Lancrenon S, Millet V (1993). "[Comparative double-blind study of bromazepam versus prazepam in non-psychotic anxiety]" (in French). Encephale 19 (5): 547–52. PMID 8306923. 
  7. ^ Chalmers, P; Horton, Jn (Apr 1984). "Oral bromazepam in premedication. A comparison with diazepam.". Anaesthesia 39 (4): 370–2. doi:10.1111/j.1365-2044.1984.tb07280.x. ISSN 0003-2409. PMID 6143514. 
  8. ^ Liljequist R; Linnoila M, Mattila MJ, Saario I, Seppälä T (October 1975). "Effect of two weeks' treatment with thioridazine, chlorpromazine, sulpiride and bromazepam, alone or in combination with alcohol, on learning and memory in man". Psychopharmacologia 44 (2): 205–8. doi:10.1007/BF00421011. PMID 710. 
  9. ^ Münte TF, Gehde E, Johannes S, Seewald M, Heinze HJ (1996). "Effects of alprazolam and bromazepam on visual search and verbal recognition memory in humans: a study with event-related brain potentials". Neuropsychobiology 34 (1): 49–56. doi:10.1159/000119291. PMID 8884760. 
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