Girisopam

Drugbox
IUPAC_name = 1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine

---

width=180
CAS_number=82230-53-3
ATC_prefix=
ATC_suffix=
ATC_supplemental=
PubChem=71257
DrugBank=
C=18 | H=17 | Cl=1 | N=2 | O=2
molecular_weight = 328.79
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

Girisopam (GYKI-51189) is a drug which is a 2,3-benzodiazepine derivative, related to tofisopam. It has selective anxiolytic action with no sedative, anticonvulsant or muscle relaxant effects. [Andrási F, Horváth K, Sineger E, Berzsenyi P, Borsy J, Kenessey A, Tarr M, Láng T, Kórösi J, Hámori T. Neuropharmacology of a new psychotropic 2,3-benzodiazepine. "Arzneimittelforschung". 1987 Oct;37(10):1119-24.] [Horváth K, Andrási F, Botka P, Hámori T. Anxiolytic profile of girisopam and GYKI 52,322 (EGIS 6775). Comparison with chlordiazepoxide and buspirone. "Acta Physiologica Hungarica". 1992;79(2):153-61.] [Horváth EJ, Salamon C, Bakonyi A, Fekete MI, Palkovits M. [(3)H] -girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site. "Brain Research. Brain Research Protocols". 1999 Jul;4(2):230-5.]

References

[http://www.psychotropics.dk/usr_view_molecule.asp?ID=1423&backurl=Codeindex%2Fview%5FCodes%2Easp%3FStartchar%3DC&backurlname=Code+numbers&Catalogtype=A&historyline=]