- Ciclotizolam
-
Ciclotizolam 
Systematic (IUPAC) name 2-Bromo-4-(o-chlorophenyl)-9-cyclohexyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepine Clinical data Pregnancy cat. ? Legal status ? Identifiers CAS number 58765-21-2 
ATC code None PubChem CID 71949 ChemSpider 64956 UNII JK517QTN4Q Chemical data Formula C20H18BrClN4S Mol. mass 461.806 SMILES eMolecules & PubChem - InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2
Key:ZOSHXIXUCKESEG-UHFFFAOYSA-N
(what is this?) (verify)Ciclotizolam[1] (WE-973) is a drug which is a thienobenzodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.[2][3]
See also
References
- ^ DE Patent 2445430
- ^ Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P (February 1985). "Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines')". European Journal of Pharmacology 109 (1): 19–31. doi:10.1016/0014-2999(85)90535-7. PMID 2986988.
- ^ Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI (1989). "Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles". Life Sciences 45 (4): 349–58. doi:10.1016/0024-3205(89)90145-8. PMID 2569655.
Benzodiazepine derivatives 1,4-Benzodiazepines Bromazepam · Camazepam · Carburazepam · Chlordiazepoxide · Cinolazepam · Clonazepam · Clorazepate · Cyprazepam · Delorazepam · Demoxepam · Devazepide * · Diazepam · Doxefazepam · Elfazepam · Ethyl carfluzepate · Ethyl dirazepate · Ethyl loflazepate · Fletazepam · Fludiazepam · Flunitrazepam · Flurazepam · Flutemazepam · Flutoprazepam · Fosazepam · Gidazepam · Halazepam · Iclazepam · Ketazolam · Lorazepam · Lormetazepam · Meclonazepam · Medazepam · Menitrazepam · Metaclazepam · Motrazepam · Nimetazepam · Nitrazepam · Nitrazepate · Nordazepam · Nortetrazepam · Oxazepam · Phenazepam · Pinazepam · Pivoxazepam · Prazepam · Proflazepam · Quazepam · QH-II-66 · Reclazepam · Ro5-2904 · Ro5-4864 * · Sulazepam · Temazepam · Tetrazepam · Tifluadom * · Tolufazepam · Tuclazepam · Uldazepam
1,5-Benzodiazepines Arfendazam · Clobazam · CP-1414S · Lofendazam · Triflubazam
2,3-Benzodiazepines * Girisopam · GYKI-52466 · GYKI-52895 · Nerisopam · Talampanel · Tofisopam
Triazolobenzodiazepines Adinazolam · Alprazolam · Estazolam · Flubromazolam · Triazolam
Imidazobenzodiazepines Bretazenil · Climazolam · FG-8205 · Flumazenil · Imidazenil · L-655,708 · Loprazolam · Midazolam · PWZ-029 · Remimazolam · Ro15-4513 · Ro48-6791 · Ro48-8684 · Sarmazenil · SH-053-R-CH3-2′F
Oxazolobenzodiazepines Cloxazolam · Flutazolam · Haloxazolam · Mexazolam · Oxazolam
Thienodiazepines Bentazepam · Brotizolam · Ciclotizolam · Clotiazepam · Etizolam · Olanzapine *
Pyridodiazepines Lopirazepam · Zapizolam
Pyrazolodiazepines Pyrrolodiazepines Tetrahydroisoquinobenzodiazepines Benzodiazepine prodrugs * atypical activity profile (not GABAA receptor ligands)
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. - InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2
