Lofendazam

Drugbox
IUPAC_name = 8-chloro-1-phenyl-4,5-dihydro-3H-1,5-benzodiazepin-2-one

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CAS_number=29176-29-2
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PubChem=71709
smiles = Clc1ccc2NCCC(=O)N(c3ccccc3)c2c1
DrugBank=
C=15 | H=13 | Cl=1 | N=2 | O=1
molecular_weight = 272.73
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Lofendazam is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. [Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones. "Liebigs Annalen der Chemie", 1995. (10):1861-1869.] [Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones. "Organic Magnetic Resonance", 1981. 15(4):394-398]

Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam. [J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. "The Pharmacology of Sleep". Springer. ISBN 978-3540589617]

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