- Etizolam
Drugbox
IUPAC_name = ?
CAS_number=40054-69-1
ATC_prefix=N05
ATC_suffix=BA19
ATC_supplemental=
PubChem=3307
DrugBank=?
C=17 | H=15 | Cl=1 | N=4 | S=1
molecular_weight = 342.8
bioavailability= 93%
metabolism = Hepatic
elimination_half-life= about 6 hours
excretion = Renal
pregnancy_category = ?
legal_US = Schedule IV
routes_of_administration= OralEtizolam (marketed under the brand name Sedekopan or Depas) is a drug which is a
benzodiazepine derivative. It possessesanxiolytic ,anticonvulsant ,sedative andskeletal muscle relaxant properties.Etizolam is not approved for sale in the
United States orCanada .Indications
* Short-term treatment of
insomnia
* Short-term treatment ofanxiety orpanic attack s, if a benzodiazepine is requiredDosage
* For anxiety: 0,25-0,50 mg two or three times per day (maximum 2 mg per day)
* For insomnia: 1 or 2 mg before bedtimePharmacology
According to the Italian P.I. sheet (please correct my poor English please):
Etizolam belongs to a new class of
diazepine s,thienotriazolodiazepines . This new class is easily oxidized, rapidly metabolized, and has a lower risk of accumulation, even after prolonged treatment. Etizolam has ananxiolytic action about 6 times greater than that ofdiazepam . Etizolam produces, especially at higher dosages, a reduction in time taken to fall asleep, an increase in total sleep time and a reduction in the number of awakenings. During tests there were not substantial changes in deep sleep. There is a reduction of REM sleep, but REM rebound at the end of treatment was not seen. In EEG tests of healthy volunteers Etizolam showed some characteristics oftricyclic antidepressant s. Etizolam is free of significant effects on the cardiovascular and respiratory systems.In men, peak time is at 3.2 hours, and half-life is about 6.2 hours. So it can be classified as a short-medium action
bendodiazepine .External links
* [http://www.inchem.org/documents/pims/pharm/pim926.htm Inchem.org - Etizolam]
* [http://www.carloanibaldi.com/terapia/schede/DEPAS.htm Italian P.I. Sheet]
Wikimedia Foundation. 2010.
