(+)-cis-2-Aminomethylcyclopropane carboxylic acid

(+)-cis-2-Aminomethylcyclopropane carboxylic acid


(+)-cis-2-Aminomethylcyclopropane carboxylic acid
Systematic name
(1S,2R)-2-(Aminomethyl)cyclopropane-1-carboxylic acid[1]
Identifiers
CAS number 36489-13-1 N
PubChem 1502041
ChemSpider 1236854 YesY
ChEMBL CHEMBL230115 YesY
Jmol-3D images Image 1
Properties
Molecular formula C5NH9O2
Molar mass 115.1305 g mol-1
Exact mass 115.063328537 g mol-1
log P -0.721
Acidity (pKa) 4.157
Basicity (pKb) 9.840
Isoelectric point 7.01
 N carboxylic acid (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

(+)-cis-2-Aminomethylcyclopropane carboxylic acid ((+)-CAMP) is a GABA agonist selective for the GABAA-ρ (previously known as GABAC) subtype.[2][3]

References

  1. ^ "AC1LT400 - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 11 July 2005. Identification and Related Records. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1502041. Retrieved 7 October 2011. 
  2. ^ Duke, RK; Chebib, M; Balcar, VJ; Allan, RD; Mewett, KN; Johnston, GA (2000). "(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors". Journal of neurochemistry 75 (6): 2602–10. PMID 11080214. 
  3. ^ Carland, JE; Moorhouse, AJ; Barry, PH; Johnston, GA; Chebib, M (2004). "Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability". The Journal of biological chemistry 279 (52): 54153–60. doi:10.1074/jbc.M410625200. PMID 15485818. 
v · d · eGABAergics
Receptor
ligands

Agonists: Main site: Bamaluzole • Gaboxadol • Ibotenic acid • Isoguvacine • Isonipecotic acid • Muscimol (Amanita Muscaria) • Progabide • SL 75102 • Thiomuscimol • Tolgabide; Positive allosteric modulators: Barbiturates • Benzodiazepines • Carbamates • Chlormezanone • Clomethiazole • Ethanol (Alcohol) • Etomidate • Kavalactones (Kava) • Loreclezole • Metomidate • Neuroactive steroids • Nonbenzodiazepines (β-Carbolines, Cyclopyrrolones, Imidazopyridines, Pyrazolopyrimidines, etc.) • Phenols • Piperidinediones • Propanidid • Pyrazolopyridines • Quinazolinones • ROD-188 • Skullcap • Stiripentol • Valerenic acid (Valerian)
* See Template:GABAAergics for a full list of GABAA positive allosteric modulators.

Antagonists: Main site: Bicuculline • Gabazine • Pitrazepin; Negative allosteric modulators: α5IA • Bilobalide • Cicutoxin • Cyclothiazide • DMCM • Flumazenil • Flurothyl • Furosemide • L-655,708 • Oenanthotoxin • Penicillin • Pentylenetetrazol • Picrotoxin • PWZ-029 • Ro15-4513 • Sarmazenil • Suritozole • Thujone (Absinthe) • Thiocolchicoside • ZK-93426
Agonists: Main site: 1,4-Butanediol • Baclofen • GBL • GHB • GHV • GVL • Lesogaberan • Phenibut • Progabide • SKF-97,541 • Tolgabide; Positive allosteric modulators: BHF-177 • BHFF • BSPP • CGP-7930 • GS-39783
Antagonists: Main site: CGP-35348 • Phaclofen • Saclofen • SCH-50911
Agonists: Main site: CACA • CAMP • GABOB • N(4)-chloroacetylcytosine arabinoside • Progabide • Tolgabide
Antagonists: Main site: Bilobalide • TPMPA
Reuptake
inhibitors
Plasmalemmal
GAT inhibitors
CI-966 • Deramciclane • EF-1502 • Gabaculine • Guvacine • Nipecotic acid • NNC 05-2090 • SKF-89976A • SNAP-5114 • Tiagabine
Enzyme
inhibitors
GAD inhibitors
Allylglycine
GABA-T inhibitors
3-Hydrazinopropionic acid • Aminooxyacetic acid • Gabaculine • Isoniazid • Phenelzine • Phenylethylidenehydrazine • Sodium valproate • Valnoctamide • Valproate pivoxil • Valproate semisodium (Divalproex sodium) • Valproic acid • Valpromide • Vigabatrin
Others
Glutamate • Glutamine
Others
Gabapentin • L-Theanine • Picamilon • Pregabalin


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