3-Iodothyronamine

3-Iodothyronamine

Chembox new
ImageFile = 3-Iodothyronamine.png ImageSize =
IUPACName = 4- [4-(2-Amino-ethyl)-2-iodo-phenoxy] -phenol
OtherNames = T1AM
Section1 = Chembox Identifiers
CASNo = 712349-95-6
PubChem =
SMILES = OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1
Section2 = Chembox Properties
Formula = C14H14INO2
MolarMass = 355.17 g/mol
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Density =
MeltingPt =
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Section3 = Chembox Hazards
MainHazards =
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3-iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor. [cite journal |author=Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D |title=3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone |journal=Nat. Med. |volume=10 |issue=6 |pages=638–42 |year=2004 |pmid=15146179 |doi=10.1038/nm1051] [cite journal |author=Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T |title=Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues |journal=J. Med. Chem. |volume=49 |issue=3 |pages=1101–12 |year=2006 |pmid=16451074 |doi=10.1021/jm0505718] When injected into rodents, T1AM causes a rapid drop in body temperature and alterations in blood pressure and heart rate. [cite web |url=http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php |title=New compound may act to keep thyroid activity in check |format= |work= |accessdate=2008-05-30]

T1AM may be part of a signaling pathway to modulate cardiac function as the compound can induce negative inotropic effects and decrease cardiac output. [cite journal |author=Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. |title=Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function |journal= |volume= |issue= |pages= |year=2007 |pmid=17284482]

ee also

* Trace amine

External links

*

References


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