- Niclosamide
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Niclosamide 
Systematic (IUPAC) name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide Clinical data AHFS/Drugs.com Micromedex Detailed Consumer Information Pregnancy cat. ? Legal status ? Identifiers CAS number 50-65-7 
ATC code P02DA01 QP52AG03 PubChem CID 4477 DrugBank DB06803 ChemSpider 4322 UNII 8KK8CQ2K8G 
KEGG D00436 ChEMBL CHEMBL1448 Chemical data Formula C13H8Cl2N2O4 Mol. mass 327.119 g/mol SMILES eMolecules & PubChem - InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Key:RJMUSRYZPJIFPJ-UHFFFAOYSA-N
(what is this?) (verify)Niclosamide (trade name Niclocide) is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide.It is stressed that while antihelmintics are a drug family used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight. Niclosamide molecules are lethal to tapeworms upon contact.
Side effects
The medication can have side effects such as abdominal pain, anorexia, diarrhea, and emesis. Rarely, dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste.
Mechanism of action
According to an article in Nature,[1] niclosamide uncouples oxidative phosphorylation in the tapeworm.
References
- ^ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature 221 (5185): 1016–8. doi:10.1038/2211016a0. PMID 4180173.
- Taber, Clarence Wilbur; Venes, Donald; Thomas, Clayton L. (2001). Taber's cyclopedic medical dictionary. Philadelphia: F.A.Davis Co.
- Additional Medication Information:Medline
- http://www.drugs.com/cons/Niclosamide.html
Antiparasitics – Anthelmintics (P02) Antiplatyhelmintic agents Antitrematodals
(schistosomicides)Binds tubulinOther/unknownquinoline (Praziquantel#, Oxamniquine#) • phenol (Bithionol) • thiazole (Niridazole) • arylsulfonate (Stibophen)Anticestodals
(taeniacides)Binds tubulinOther/unknownsalicylanilide (Niclosamide)# • aminoacridine (Quinacrine) • butyrophenone (Desaspidin) • chlorophenol (Dichlorophen)Antinematodal agents
(including
macrofilaricides)Binds tubulinbenzimidazole (Mebendazole#, Albendazole#, Thiabendazole, Fenbendazole, Ciclobendazole, Flubendazole)Other/unknownpiperazine (Piperazine • Diethylcarbamazine#) • thiazole (Levamisole#) • quinolinium (Pyrvinium) • benzylammonium (Bephenium) • naphthalenesulfonate (Suramin#) • TribendimidineM: IFT
helm,arth (acar)
helm, arth (lice), zoon
helm, arth
This antiinfective drug article is a stub. You can help Wikipedia by expanding it. - InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
