Systematic (IUPAC) name
Clinical data
AHFS/ monograph
Pregnancy cat. C
Legal status  ?
CAS number 483-63-6 YesY
ATCvet code QP53AX04
PubChem CID 688020
DrugBank DB00265
ChemSpider 599515 YesY
KEGG D01381 YesY
Chemical data
Formula C13H17NO 
Mol. mass 203.28 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug). It is a prescription and OTC lotion based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causes itching.



For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied 2 to 3 times, with a 24 hour delay in between applications, and the patient is asked to take a shower no sooner than after 48 hours. For children under 3 years it is applied once daily. Crotamiton can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.


The mechanism of action of crotamiton is unknown, but it is toxic to the scabies mite.[2]


After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.[3]

Side effects

The most common side effect of crotamiton is skin irritation.

Trade name

Crotamiton is marketed under the trade names Eurax, which is manufactured by Novartis in the UK, and Euracin, which is manufactured by Green Cross in South Korea.