- Procyclidine hydrochloride
IUPAC_name = 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride
CAS_number = 77-37-2
ATC_prefix = N04
ATC_suffix = AA04
PubChem = 207841
DrugBank = APRD00383
C=19 | H=30 | Cl=1 | N=1 | O=1
molecular_weight = 323.9 g/mol
protein_bound = ~100%-albumin
elimination_half-life = ~12 h
routes_of_administration = oral, im, iv
Procyclidine hydrochloride is an
anticholinergicdrug principally used for the treatment of:
parkinsonism, akathisiaand acute dystonia;
Parkinson disease; and
Idiopathicor secondary dystonia.
It is used in patients with
schizophreniato reduce the side effects of antipsychotictreatment, such as parkinsonismand akathisia.
Procyclidine is also a second-line drug for the treatment of
Parkinson's disease. It improves tremorbut not rigidity or bradykinesia.
Procyclidine is also sometimes used for the treatment of
dystonia(but not tardive dyskinesia), a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.
igns of Overdose
Signs of procyclidine overdose are those of an
anticholinergicand include confusion, agitation and sleeplessness that can last up to or more than 24 hours. Pupils become dilated and unreactive to light. Tachycardia(fast heart beat), as well as auditory and visual hallucinations have also been reported.
Other known symptoms of overdose are: clumsiness or unsteadiness, being severely drowsy, having a severely dry mouth, nose, or throat, having an altered mood or other mental changes, seizures, being short of breath or having troubled breathing, a dry and warm, flushed skin.
A suspected overdose with severe life-threatening symptoms should immediately be brought to medical attention, where reversal can be attempted with
physostigmineadministered intravenously or subcutaneously.
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