- Salsalate
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Salsalate 
Systematic (IUPAC) name 2-(2-Hydroxybenzoyl)oxybenzoic acid Clinical data Trade names Disalcid, Salflex AHFS/Drugs.com monograph MedlinePlus a682880 Pregnancy cat. C Legal status ? Identifiers CAS number 552-94-3 
ATC code N02BA06 PubChem CID 5161 DrugBank DB01399 ChemSpider 4977 
UNII V9MO595C9I KEGG D00428 Chemical data Formula C14H10O5 Mol. mass 258.23 g/mol 
(what is this?) (verify)Salsalate is a non-steroidal anti-inflammatory drug (NSAID). Salsalate is in a class of drugs called salicylates. Salsalate may work by inhibiting the production of and release of prostaglandins. Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.[1]
Typical Use
Salsalate is used to reduce pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, and related rheumatic conditions. Salsalate is also recommended by physicians as an anti-inflammatory alternative to naproxen, and ibuprofen for patients that have had minor stomach bleeding or stomach upset. It has also been used as an alternative to narcotic pain medicine for people with spinal disc protrusion.
"In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo." [2]
Research on use to prevent or treat Type II Diabetes
The Wall Street Journal Health Blog reported on research on using Salsalate to prevent or treat type II diabetes: "In a 20-patient, month-long study, the fasting glucose levels of those who took salsalate declined 13% compared with those who took a placebo. The results, published in the Feb. issue of Diabetes Care, suggest that the drug reduces blood sugar in obese adults who don’t have diabetes, apparently by making insulin work better."[3]
On March 20, 2010, The Joslin Diabetes Center , Boston, MA, released a report entitled: Generic Drug for Type 2 Diabetes Passes Next Clinical Hurdle - "Salsalate, an anti-inflammatory agent, shows encouraging results in preliminary trial"[4]
References
Anti-inflammatory products (M01A) Pyrazolidine/Butylpyrazolidines Ampyrone • Clofezone • Kebuzone • Metamizole • Mofebutazone • Oxyphenbutazone • Phenazone • Phenylbutazone • Sulfinpyrazone • Feprazone •Acetic acid derivatives
and related substancesAceclofenac • Acemetacin • Alclofenac • Bromfenac • Bumadizone • Bufexamac • Diclofenac • Difenpiramide • Etodolac • Fentiazac • Indometacin • Ketorolac • Lonazolac • Oxametacin • Proglumetacin • Sulindac • Tolmetin • Zomepirac • AmfenacOxicams Propionic acid derivatives Alminoprofen • Benoxaprofen • Dexibuprofen • Dexketoprofen • Fenbufen • Fenoprofen • Flunoxaprofen • Flurbiprofen • Ibuprofen • Ibuproxam • Indoprofen • Ketoprofen • Naproxen • Oxaprozin • Pirprofen • Suprofen • Tiaprofenic acidFenamates Coxibs Other Salicylic acid • Aspirin • Aloxiprin • Methyl salicylate • Magnesium salicylate • Ethyl salicylate • Bismuth subsalicylate • Sodium salicylate • Salicylamide • Salicin • Benorilate • Salsalate • Ethenzamide • Diflunisal • Trolamine salicylate • Homosalate • Salicylmethylecgonine • Octyl salicylate • Aluminon • Benzyl salicylate • Copper aspirinate • Potassium salicylateCategories:- Non-steroidal anti-inflammatory drugs
- Salicylates
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