Dexketoprofen

Dexketoprofen
Dexketoprofen
Systematic (IUPAC) name
(2S)-2-[3-(benzoyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status POM (UK)
Identifiers
ATC code M01AE17
PubChem CID 667550
UNII 6KD9E78X68 YesY
KEGG D07269 YesY
Chemical data
Formula C16H14O3 
Mol. mass 254.28056 g/mol
 YesY(what is this?)  (verify)

Dexketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as dexketoprofen trometamol, as a prescription-only drug and in Latin America as Miracox, produced by Stein in Costa Rica.

Contents

Indications

Short-term treatment of mild to moderate pain, including dysmenorrhoea.

How does it work

Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.

Warning

  1. This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
  2. For fast relief of pain, take at least 30 minutes before food, as food delays the absorption of this medicine from the gut.
  3. This medicine is not for long term use

Use with caution in

  1. Decreased heart function
  2. Disorders involving the formation of blood cells (haematopoietic disorders)
  3. Elderly people
  4. Excess retention of water in the body tissues (fluid retention)
  5. History of allergies
  6. Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
  7. Low volume of circulating blood (hypovolaemia)
  8. Mild to moderately decreased liver function
  9. Mildly decreased kidney function
  10. Syndrome with symptoms of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon (mixed connective tissue disease)

Not to be used in

  1. Active bleeding
  2. Allergy to any of its ingredients
  3. Allergy to aspirin or other medicines in this class
  4. Asthma or history of asthma
  5. Bleeding disorders
  6. Bleeding from the stomach or intestines
  7. Breastfeeding
  8. Children
  9. Crohn's disease
  10. History of stomach or duodenal ulcers or indigestion
  11. Inflammation of the bowel and back passage
  12. Inherited tendency to bleed (haemorrhagic diathesis)
  13. Moderate to severely decreased kidney function
  14. Peptic ulcers
  15. Pregnancy
  16. Severe heart failure
  17. Severely decreased liver function

Label warnings

  1. Take this medication half to one hour before eating in order to facilitate quick absorption in case of acute pain. As a precautionary measure, it is advised to take dexketoprofen during meals at a interval of 8 hours.

Dose

In the USA: Adult: 12.5mg every 4-6 hours, or 25mg every 8 hours; max 75mg daily. Elderly: initially max 50mg daily. Child: not recommended.

In Europe: As prescribed, the dosage is variable being consistent with the nature, severity and duration of the pain episode. Currently the prescribed amount is 25mg every 8 hours, although the daily dosage should not exceed 75mg. In elederly pacients, light to moderate liver and renal failure, the maximum dosage is set at a maximum of 50mg/24h. Dexketoprofen is currently not prescribed to children under the age of 18.

Citations

[1]

v · d · eAnti-inflammatory products (M01A)
Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
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M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)
v · d · eNon-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
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COX-inhibiting nitric oxide donators
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Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
v · d · eAnalgesics (N02A, N02B)
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Non-steroidal
anti-inflammatories
See also: NSAIDs template
Propionic acid class
Oxicam class
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Anthranilic acid
(fenamate) class

Meclofenamate • Mefenamic acid
Salicylates
Atypical, adjuvant and potentiators,
Metabolic agents and miscellaneous
Amitryptiline  • Befiradol • Bicifadine • Carisoprodol  • Camphor • Cimetidine • Clonidine • Chlorzoxazone • Cyclobenzaprine • Duloxetine • Esreboxetine • Flupirtine • Gabapentin • Glafenine • Hydroxyzine • Ketamine  • Menthol • Mephenoxalone • Methocarbamol • Nefopam • Orphenadrine • Pregabalin • Proglumide • Scopolamine • Tebanicline • Trazodone • Gabapentin enacarbil • Ziconotide

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)


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