Proglumetacin

Drugbox
IUPAC_name = 3- [4- [2- [2- [1-(4-chlorobenzoyl)-5-methoxy-2-
methylindol-3-yl] acetyl] oxyethyl] piperazin-1-yl]
propyl 4-(benzoylamino)-5-(dipropylamino)-
5-oxopentanoate

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CAS_number = 57132-53-3
CAS_supplemental = CAS|59209-40-4 (maleate)
ATC_prefix = M01
ATC_suffix = AB14
PubChem = 4921
DrugBank =
C=46|H=58|Cl=1|N=5|O=8
molecular_weight = 844.43442 g/mol
bioavailability =
protein_bound =
metabolism = Hepatic. Undergoes enterohepatic recirculation
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Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide, [cite journal |author=Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L |title=Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog |journal=Arzneimittel-Forschung |volume=37 |issue=6 |pages=698–702 |year=1987 |pmid=3663267 |doi=] a drug with effects that helps prevent injury to the stomach lining.

References