Flupirtine

Drugbox
IUPAC_name = ethyl {2-amino-6- [(4-fluorobenzyl)amino] pyridin-3-yl}carbamate

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CAS_number = 56995-20-1
ATC_prefix = N02
ATC_suffix = BG07
PubChem = 53276
DrugBank =
C=15|H=17|F=1|N=4|O=2
molecular_weight = 304.32 g/mol
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Flupirtine is an aminopyridine.

It has been used as an analgesic.cite journal |author=Swedberg MD, Shannon HE, Nickel B, Goldberg SR |title=Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat |journal=J. Pharmacol. Exp. Ther. |volume=246 |issue=3 |pages=1067–74 |year=1988 |month=September |pmid=2901483 |doi= |url=http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2901483]

It has been proposed as a possible treatment for Batten disease.cite journal |author=Dhar S, Bitting RL, Rylova SN, "et al" |title=Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons |journal=Ann. Neurol. |volume=51 |issue=4 |pages=448–66 |year=2002 |month=April |pmid=11921051 |doi= |url=http://dx.doi.org/10.1002/ana.10143]

References