Niflumic acid

Niflumic acid
Niflumic acid
Systematic (IUPAC) name
2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?(AU)
Legal status  ?
Pharmacokinetic data
Half-life 2.5 hr [1]
Identifiers
CAS number 4394-00-7 YesY
ATC code M02AA17
PubChem CID 4488
IUPHAR ligand 2439
UNII 4U5MP5IUD8 N
KEGG D08275 YesY
Chemical data
Formula C13H9F3N2O2 
Mol. mass 282.21797 g/mol
 N(what is this?)  acid (verify)

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels[2]. It has also been reported to act on GABA-A and NMDA channels [3].

v · d · eAnti-inflammatory products (M01A)
Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)
v · d · eTopical products for joint and muscular pain (M02)
Anti-inflammatory preparations,
non-steroids
Acetic acid derivatives
Other
Benzydamine • Etofenamate • Piroxicam • Felbinac • Bufexamac • Ketoprofen • Bendazac • Naproxen • Ibuprofen • Feprazone • Niflumic acid • Meclofenamic acid • Flurbiprofen • Suxibuzone • Indometacin • Nifenazone
Capsaicin derivatives
Other
Tolazoline • Dimethyl sulfoxide • Idrocilamide


References

  1. ^ "Half life". Drug Bank. http://www.drugbank.ca/drugs/DB04552. Retrieved 15 July 2011. 
  2. ^ Knauf, Philip A.; Mann, Nancy A (1984). J. Gen. Physiol. 83: 703–725. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2215658. 
  3. ^ Lerma J., Martin d.R. (1992). Mol. Pharmacol. 41: 217–222. PMID 1371581. 


Stub icon This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.