Chlorzoxazone

Chlorzoxazone

Systematic (IUPAC) name
5-chloro-3H-benzooxazol-2-one
Clinical data
Trade names	Parafonforte
AHFS/Drugs.com	monograph
MedlinePlus	a682577
Pregnancy cat.	?
Legal status	?
Routes	oral
Pharmacokinetic data
Bioavailability	well absorbed
Protein binding	13–18%
Metabolism	hepatic
Half-life	1.1 hr
Excretion	urine (<1%)
Identifiers
CAS number	95-25-0 Y
ATC code	M03BB03
PubChem	CID 2733
DrugBank	APRD00308
ChemSpider	2632 Y
UNII	H0DE420U8G Y
KEGG	D00771 Y
ChEBI	CHEBI:3655 Y
ChEMBL	CHEMBL1371 Y
Chemical data
Formula	C7H4ClNO2
Mol. mass	169.565 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10) Y Key:TZFWDZFKRBELIQ-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Muscol or Parafon Forte, a combination of chlorzoxazone and acetaminophen (Paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity, which is why the combination is not recommended. For a more in depth look at Chlorzoxazone visit http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=15262.

Chemistry

Chlorzoxazone, 5-chloro-2-benzoxazolione, is synthesized by a hetercyclization reaction of 2-amino-4-chlorphenol with phosgene.

• D.F. Marsh, U.S. Patent 2,895,877 (1959).

External links

• Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta". Eur J Pharmacol 545 (2–3): 161–6. doi:10.1016/j.ejphar.2006.06.063. PMID 16859676. 
• Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe". J Clin Pharmacol 46 (1): 109–14. doi:10.1177/0091270005282635. PMID 16397290. 
• Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats". J Pharm Pharmacol 58 (1): 51–61. doi:10.1211/jpp.58.1.0007. PMC 1388188. PMID 16393464. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1388188. 

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.v · Categories: Muscle relaxants Carbamates Organochlorides Benzoxazoles Musculoskeletal system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Kildangan GAA Latin American cinema Look at other dictionaries: chlorzoxazone — noun A particular muscle relaxant …   Wiktionary chlorzoxazone — A centrally acting skeletal muscle relaxant used in the treatment of painful muscle spasm due to musculoskeletal disorder. * * * chlor·zox·a·zone (klor zokґsə zōn) a skeletal muscle relaxant, used to relieve discomfort of painful… …   Medical dictionary Parafon Forte — is a combination of chlorzoxazone and acetaminophen.* Not commercially available in the U.S. Category Analgesic skeletal muscle relaxant DescriptionChlorzoxazone and acetaminophen (klor ZOX a zone and a seat a MIN oh fen) combination medicine is… …   Wikipedia ATC code M03 — A section of the Anatomical Therapeutic Chemical Classification System.M Musculo skeletal systemM03A Muscle relaxants, peripherally acting agentsM03AA Curare alkaloids:M03AA01 Alcuronium:M03AA02 Tubocurarine:M03AA04 DimethyltubocurarineM03AB… …   Wikipedia Muscle relaxant — This article refers to skeletal muscle relaxants. For information on smooth muscle relaxants, see Antispasmodic. A muscle relaxant is a drug which affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate… …   Wikipedia Watercress — For the vegetable sometimes called Chinese watercress, see Ipomoea aquatica. Nasturtium Nasturtium officinale Scientific classification Kingdom …   Wikipedia Carisoprodol — Systematic (IUPAC) name 2 {[(aminocarbonyl)oxy]me …   Wikipedia Cytochrome P450 — Oxidase (CYP2C9) Identifiers Symbol p450 Pfam …   Wikipedia Orphenadrine — Systematic (IUPAC) name N,N dimethyl 2 [(2 methylphenyl) phenyl methoxy] ethanamine Clinical data Trade names …   Wikipedia Nicotinic agonist — A nicotinic agonist is a drug which enhances the action at the nicotinic acetylcholine receptor (nAChR). Examples include: nicotine (by definition the nicotinic acetylcholine receptor is named for its affinity for nicotine) acetylcholine, the… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”