Pancuronium bromide

Pancuronium bromide
Pancuronium
Systematic (IUPAC) name
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-
17-acetyloxy-10,13-dimethyl-2,16-bis(1-methyl-
3,4,5,6-tetrahydro-2H-pyridin-1-yl)-2,3,4,5,6,7,
8,9,11,12,14,15,16,17-tetradecahydro-1H-
cyclopenta[a]phenanthren-3-yl] acetate
Clinical data
AHFS/Drugs.com monograph
Pregnancy cat. B2(AU) C(US)
Legal status POM (UK) ℞-only (US)
Routes Intravenous
Pharmacokinetic data
Bioavailability NA
Protein binding 77 to 91%
Metabolism Hepatic
Half-life 1.5 to 2.7 hours
Excretion Renal and biliary
Identifiers
CAS number 16974-53-1 YesY
15500-66-0 (bromide)
ATC code M03AC01
PubChem CID 441289
DrugBank DB01337
ChemSpider 25453 N
UNII U9LY9Y75X2 N
KEGG D00492 YesY
ChEBI CHEBI:7908 N
ChEMBL CHEMBL185073 N
Chemical data
Formula C35H60N2O4 
Mol. mass 572.861 g/mol
 N(what is this?)  bromide (verify)

Pancuronium (Pavulon) is a muscle relaxant with various purposes. It is the second of three drugs administered during most lethal injections in the United States.

Contents

Mode of action

Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration. Despite being a steroid, pancuronium has no hormonal activity. It exerts slight vagolytic activity (i.e. diminishing activity of the vagus nerve) and no ganglioplegic (i.e. blocking ganglions) activity. Pancuronium is a very potent muscle relaxant/curaremimetic. The ED95 (i.e. a dose causing a 95% reduction in muscle activity) is only 60 µg/kg body weight administered intravenously. Muscle relaxation suitable for intubation sets in about 90–120 seconds after administration of the drug. Full muscle paralysis for major surgery is achieved about 2–4 minutes after application. Clinical effects (muscle activity lower than 25% of physiological) last for about 100 minutes. The time needed for full (over 90% muscle activity) recovery after single administration is about 120–180 minutes in healthy adults, but can be protracted to more hours in poor health subjects and when concomitantly administered with other long-acting anesthetics (e.g., some opioids, barbiturates, inhalation anesthetics). The effects of pancuronium can be at least partially reversed by anticholinesterasics, such as neostigmine, pyridostigmine, and edrophonium.

Development

Pancuronium is designed to be like two molecules of acetylcholine with the quaternary nitrogen atoms spaced rigidly apart by the steroid rings at a distance of ten atoms (interonium distance). Decamethonium and suxamethonium also have this same interonium distance.

Uses in medicine

Pancuronium is used with general anaesthesia in surgery for muscle relaxation and as an aid to intubation or ventilation. It does not have sedative or analgesic effects.

Side-effects include moderately raised heart rate and thereby arterial pressure and cardiac output, excessive salivation, apnea and respiratory depression, rashes, flushing, and sweating. The muscular relaxation can be dangerous in the seriously ill and it can accumulate leading to extended weakness. Pancuronium is not preferable in long-term use in ICU-ventilated patients.

In Belgium and the Netherlands, pancuronium is recommended in the protocol for euthanasia. After administering sodium thiopental to induce coma, pancuronium is delivered in order to stop breathing.[1]

In 2007, Dr Michael Munro, a Scottish neonatologist at Aberdeen Maternity Hospital, was cleared of malpractice by the GMC Fitness to Practice panel after giving 23 times the standard dose of pancuronium to two dying neonates. In the final minutes of life, each baby was suffering from agonal gasping and violent body spasms, which was highly distressing for the parents to witness. Dr Munro then administered pancuronium to the babies after advising the parents that this would ease their suffering, but could also hasten death.[2][3] It is on record that neither of the children's parents was unhappy with Dr Munro's treatment of their babies.[4]

Uses in execution

Procedure

It is also used as one component of a lethal injection in administration of the death penalty in some parts of the United States.[5]

Controversy

Pancuronium bromide has no hypnotic effects, and, if the anaesthetic agent used in lethal injection is ineffective, an individual could, it is presumed, never achieve unconsciousness, and thus be able to feel all of the pain associated with the procedure, but unable to cry out or move due to the pancuronium's complete paralytic action. There have also been several high-profile civil lawsuits alleging similar failures to achieve analgesia or unconsciousness prior to a general surgical procedures. These, too, have been blamed largely on improper or insufficient dosages of anaesthetic in concert with normal dosages of pancuronium bromide.

Echoing this sentiment, Amnesty International has objected to its use in lethal injections on the grounds that it "may mask the condemned prisoner's suffering during the execution,"[6] thereby leading observers to conclude that lethal injection is painless, or less cruel than other forms of execution.

In September 2007, the US Supreme Court agreed to hear their first case of whether or not the use of lethal injection does in fact violate the US Constitution's Eighth Amendment's ban on cruel and unusual punishment.[7] On April 16, 2008, the court upheld the constitutionality of Kentucky's lethal injection practices.[8]

Uses in crime

Pancuronium is the compound that was used in Efren Saldivar's killing spree.[9] It was also used by the Skin Hunters to kill patients in the Polish city of Łódź. Pavulon was also used by Richard Angelo in 1987 to kill at least 10 patients under his care at the Good Samaritan Hospital in New York.

References

  1. ^ "Administration and Compounding Of Euthanasic Agents". http://www.wweek.com/___ALL_OLD_HTML/euthanasics.html. Retrieved 15 July 2008. 
  2. ^ "Baby doctor cleared of misconduct". BBC News. 2007-07-11. http://news.bbc.co.uk/1/hi/scotland/north_east/6291224.stm. Retrieved 2010-05-21. 
  3. ^ "Doctor cleared over baby deaths". The Guardian. 11 July 2007. 
  4. ^ "Doctor felt babies were suffering". BBC News. 2007-07-09. http://news.bbc.co.uk/1/hi/scotland/north_east/6276900.stm. Retrieved 2010-05-21. 
  5. ^ BBC article on lethal injection. Small panel lists the chemicals used.
  6. ^ Amnesty International
  7. ^ "Court to decide lethal injection, voter ID cases". CNN. 2007. Archived from the original on 2008-01-12. http://web.archive.org/web/20080112055432/http://www.cnn.com/2007/US/law/09/25/scotus.roundup.ap/index.html#cnnSTCText. Retrieved 2007-09-25. 
  8. ^ "US Supreme Court published opinions" (PDF). US Supreme Court. 2008. http://www.supremecourt.gov/opinions/07pdf/07-5439.pdf. 
  9. ^ Crimelibrary

External links


v · d · eSkeletal muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
NMJ block)
Curare alkaloids

ultra-short duration: Gantacurium

short duration: Mivacurium  • Chandonium

intermediate duration: Atracurium  • Cisatracurium  • Fazadinium  • Rocuronium  • Vecuronium

long duration: Doxacurium • Dimethyltubocurarine • Pancuronium • Pipecuronium  • Laudexium  • Gallamine

unsorted: Hexafluronium (Hexafluorenium)

Choline derivatives: Suxamethonium (Succinylcholine)

Polyalkylene derivatives: Hexamethonium
Centrally acting
Benzodiazepines
Anticholinergics (Antimuscarinics)
Other
Directly acting

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

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Look at other dictionaries:

  • pancuronium bromide — A nondepolarizing steroidal neuromuscular blocking agent resembling curare but without its potential for ganglionic blockade, histamine release, or hypotension. * * * pan·cu·ro·ni·um bromide .pan kyə rō nē əm …   Medical dictionary

  • pancuronium bromide — ˌpankyəˈrōnēəm noun or pancuronium ( s) Etymology: perhaps from pan + cur (probably as in tubocurarine) + onium : a neuromuscular blocking agent C35H60Br2N2O4 used as a skeletal muscle relaxant …   Useful english dictionary

  • Pancuronium — drugbox IUPAC name = [(2 S ,3 S ,5 S ,8 R ,9 S ,10 S ,13 S ,14 S ,16 S ,17 R ) 17 acetyloxy 10,13 dimethyl 2,16 bis(1 methyl 3,4,5,6 tetrahydro 2 H pyridin 1 yl) 2,3,4,5,6,7, 8,9,11,12,14,15,16,17 tetradecahydro 1 H cyclopenta [ a ] phenanthren 3 …   Wikipedia

  • Pancuronium — Strukturformel    Allgemeines …   Deutsch Wikipedia

  • pancuronium — noun see pancuronium bromide …   Useful english dictionary

  • pancuronium — noun A muscle relaxant having the chemical formula CHNO, and typically administered as a bromide salt …   Wiktionary

  • Vecuronium bromide — Systematic (IUPAC) name [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17S) 17 acetyloxy 10,13 dimethyl 16 (1 methyl 3,4, 5,6 tetrahydro 2H pyridin 1 yl) 2 (1 piperidyl) 2,3,4,5,6,7 …   Wikipedia

  • Hexafluronium bromide — Hexafluronium Systematic (IUPAC) name N,N di 9H fluoren 9 yl N,N,N ,N tetramethylhexane 1,6 diaminium dibromide Clinical data …   Wikipedia

  • Ipratropium bromide — Systematic (IUPAC) name [8 methyl 8 (1 methylethyl) 8 azoniabicyclo[3.2.1] oct 3 yl] 3 hydroxy 2 phenyl propanoate Clinical data AHFS …   Wikipedia

  • Demecarium bromide — Systematic (IUPAC) name trimethyl [3 [methyl [10 [methyl (3 trimethylammoniophenoxy) carbonyl amino] decyl] carbamoyl] oxyphenyl] ammonium dibromide Clinical data …   Wikipedia

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