Alcuronium chloride

Alcuronium chloride

Drugbox
IUPAC_name = 4,4'-Didemethyl-4,4'-di-propenyltoxiferin-1-dichloride






CAS_number=23214-96-2
ATC_prefix=M03
ATC_suffix=AA01
ATC_supplemental=
PubChem=5311001
DrugBank=
C = 44 | H = 50 | N = 4 | O = 2 | charge = +2
molecular_weight = 666.894 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

Alcuronium is a peripherally acting muscle relaxant in the curare alkaloid family. It is a semi synthetic substance derived from Toxiferine.

Use - Intubation and ventilation

Action - NDMB post synapthis n2 receptor

Dose .2 - .5 mg/kg ivi

EffectsCVS- histamine release and blockage of the sympathetic ganglia including adrenal medulla could cause Hypotension

Resp- apnea due to phrenic blockage but bronchoconstriction can occur from the histamine release

CNS- no effect on intraoccular pressure

Autonomic ganglion blockade can cause decrease in gut motility

KineticsPoor oral absorption

Distribution - 40 % protein bound Volume of Distribution .37l/kg. Does cross placenta ratio .6 Metabolism - not metabolized

Excretion 70 - 90% unchanged in urine 1.3ml/kg/min t1/2 2- 4 hours

Special pointsDuration of action prolonger in states of low potassium,calcium and protein, also in staes of high magnesium and acidosis .Pharmaceutically incompatible with thiopentoneInfusion can casue fixed dilated pupils

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