Sulfinpyrazone

Sulfinpyrazone

Systematic (IUPAC) name
1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
Clinical data
Trade names	Apo-sulfinpyrazone
AHFS/Drugs.com	monograph
MedlinePlus	a682339
Pregnancy cat.	?
Legal status	?
Routes	oral intravenous
Pharmacokinetic data
Protein binding	98–99%
Metabolism	hepatic
Excretion	renal
Identifiers
CAS number	57-96-5 Y
ATC code	M04AB02
PubChem	CID 5342
DrugBank	APRD00620
ChemSpider	5149 Y
UNII	V6OFU47K3W Y
KEGG	D00449 Y
ChEBI	CHEBI:9342 N
ChEMBL	CHEMBL832 Y
Chemical data
Formula	C23H20N2O3S
Mol. mass	404.48 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2 Y Key:MBGGBVCUIVRRBF-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.

Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.

Contraindications

Sulfinpyrazone must not be used in persons with renal impairment or a high rate of excretion of uric acid (hyperuricosuria).^[1]

Synthesis

References

1. ^ Underwood M (June 2006). "Diagnosis and management of gout". BMJ 332 (7553): 1315–9. doi:10.1136/bmj.332.7553.1315. PMC 1473078. PMID 16740561. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1473078. 

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.v · Categories: Antigout agents Pyrazolidindiones Musculoskeletal system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Zasu Theodore Roosevelt High School (Gary) Look at other dictionaries: sulfinpyrazone — noun Etymology: sulfinic acid (RSO2H) + pyr + azole + one Date: 1958 a uricosuric drug C23H20N2O3S used in long term treatment of chronic gout …   New Collegiate Dictionary Sulfinpyrazone — СУЛЬФИНПИРАЗОН ( Sulfinpyrazonе )*. 1,2 Дифенил 1,4 [2 (фенилсульфинил) этил] 3,5 пиразолидиндион. Синонимы: Антуран, Аnturan, Аnturаnil, Аnturidin, Еnturan, Руrосаrd, Sulfazonе, Sulfizonе и др. Является одним из метаболитов бутадиона (см.).… …   Словарь медицинских препаратов sulfinpyrazone — /sul fin pir euh zohn /, n. Pharm. a substance, C23H20N2O3S, used in the treatment of chronic gout. [1955 60; SULFIN(YL) + PYRAZ(OLE) + ONE] * * * …   Universalium sulfinpyrazone — An analgesic and uricosuric agent, useful in gout, that promotes the excretion of uric acid, probably by interfering with the tubular reabsorption of uric acid. * * * sul·fin·py·ra·zone or chiefly Brit sul·phin·py·ra·zone .səl fən pī rə .zōn n a… …   Medical dictionary sulfinpyrazone — sul·fin·py·ra·zone …   English syllables sulfinpyrazone — sulphinpyrazone; n. a uricosuric drug given by mouth for the treatment of chronic gout. The main side effects are nausea and abdominal pain; the drug may also activate a latent duodenal ulcer and it should not be taken by patients with impaired… …   The new mediacal dictionary sulfinpyrazone — ˌsəlfə̇nˈpīrəˌzōn noun ( s) Etymology: sulfinyl + pyrazole + one : a uricosuric drug C23H20N2O3S used in long term treatment of chronic gout * * * /sul fin pir euh zohn /, n. Pharm. a substance, C23H20N2O3S, used in the treatment of chronic gout …   Useful english dictionary SPZ — sulfinpyrazone …   Medical dictionary sulphinpyrazone — sulfinpyrazone …   The new mediacal dictionary SPZ — • sulfinpyrazone …   Dictionary of medical acronyms & abbreviations 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”