- Diacerein
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Diacerein 
Systematic (IUPAC) name 4,5-diacetyloxy-9,10-dioxo-anthracene-2-
carboxylic acidClinical data AHFS/Drugs.com International Drug Names Pregnancy cat. Lacking information Legal status ? Routes Oral Pharmacokinetic data Protein binding 99% Metabolism Hepatic: deacetylation to rhein, later glucuronidation and sulfate conjugation Half-life 4 to 5 hours Excretion Renal (30%) Identifiers CAS number 13739-02-1 ATC code M01AX21 PubChem CID 26248 ChemSpider 24456 
UNII 4HU6J11EL5 KEGG D07270 ChEMBL CHEMBL41286 Synonyms Diacetylrhein, diacerhein Chemical data Formula C19H12O8 Mol. mass 368.294 g/mol SMILES eMolecules & PubChem - InChI=1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
Key:TYNLGDBUJLVSMA-UHFFFAOYSA-N
(what is this?) (verify)Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.
A 2005 Cochrane review found diacerein to be slightly, but significantly, more effective than placebo in diacerein has a small effect in improving pain and slowing the progress of osteoarthritis (in the hip). .[1]
Side effects
The most common side effects of diacerein treatment are gastrointestinal, such as diarrhea.[1][2]
References
- ^ a b Fidelix TS, Soares BG, Trevisani VF (2006). Fidelix, Tania S.A.. ed. "Diacerein for osteoarthritis". Cochrane database of systematic reviews (Online) (1): CD005117. doi:10.1002/14651858.CD005117.pub2. PMID 16437519. Free summary
- ^ (French) "Diacereine". BIAM. 1999-03-24. http://www.biam2.org/www/Sub5020.html. Retrieved 2007-06-13.
See also
Anti-inflammatory products (M01A) Pyrazolidine/Butylpyrazolidines Ampyrone • Clofezone • Kebuzone • Metamizole • Mofebutazone • Oxyphenbutazone • Phenazone • Phenylbutazone • Sulfinpyrazone • Feprazone •Acetic acid derivatives
and related substancesAceclofenac • Acemetacin • Alclofenac • Bromfenac • Bumadizone • Bufexamac • Diclofenac • Difenpiramide • Etodolac • Fentiazac • Indometacin • Ketorolac • Lonazolac • Oxametacin • Proglumetacin • Sulindac • Tolmetin • Zomepirac • AmfenacOxicams Propionic acid derivatives Alminoprofen • Benoxaprofen • Dexibuprofen • Dexketoprofen • Fenbufen • Fenoprofen • Flunoxaprofen • Flurbiprofen • Ibuprofen • Ibuproxam • Indoprofen • Ketoprofen • Naproxen • Oxaprozin • Pirprofen • Suprofen • Tiaprofenic acidFenamates Coxibs Other Nabumetone • Glucosamine • Benzydamine • Glycosaminoglycan • Magnesium salicylate • Proquazone • Superoxide dismutase/Orgotein • Nimesulide • Diacerein • Tenidap • Oxaceprol • Chondroitin sulfate
This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it. - InChI=1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
