Acemetacin

Drugbox
IUPAC_name = 2- [2- [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl] acetyl] oxyacetic acid


CAS_number = 53164-05-9
ATC_prefix = M01
ATC_suffix = AB11
PubChem = 1981
DrugBank =
C=21|H=18|Cl=1|N=1|O=6
molecular_weight = 415.82372 g/mol
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Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck under the tradename Emflex, and is available in the UK as a prescription-only drug.

Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.