Piroxicam

drugbox
IUPAC_name = (8"E")-8- [hydroxy-(pyridin-2-ylamino)methylidene] -
9-methyl-10,10-dioxo-10λ⁶-thia-9-azabicyclo [4.4.0]
deca-1,3,5-trien-7-one

---

width = 250
CAS_number = 36322-90-4
ATC_prefix = M01
ATC_suffix = AC01
ATC_supplemental = ATC|M02|AA07, ATC|S01|BC06
PubChem = 5280452
DrugBank = APRD01187
C = 15 | H = 13 | N = 3 | O = 4 | S = 1
molecular_weight = 331.348 g/mol
bioavailability =
protein_bound =
metabolism = 4 to 10% renal
elimination_half-life = 30 to 86 hours
pregnancy_category = C, D if used in the third trimester or near delivery
legal_status = POM
routes_of_administration = PO
excretion = 4 to 10% renal

Piroxicam is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is manufacturerd by Pfizer under the tradename Feldene, and is available in the UK and USA.

It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

Other brand names for Piroxicam include "Brexidol", "Brexin", "Erazon", "Felden", "Feldoral", "Hotemin", "Pirox von ct", "Proponol", "Reumador", "Tracam", "Veral", and "Vurdon".

Mechanism of action

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes enterohepatic circulation.

Adverse effects

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects. [cite web | author=New Zealand Medicines and Medical Devices Safety Authority | title=Candyl Medicines datasheet | url=http://www.medsafe.govt.nz | accessdate=2006-09-10]

Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.Fact|date=July 2007

Footnotes