Fenoprofen

Fenoprofen
Fenoprofen
Systematic (IUPAC) name
2-(3-phenoxyphenyl)propanoic acid
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a681026
Pregnancy cat. C
Legal status POM (UK)
Routes Oral
Pharmacokinetic data
Metabolism Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Half-life 3 hours
Excretion Renal (~90%)
Identifiers
CAS number 29679-58-1
ATC code M01AE04
PubChem CID 3342
DrugBank DB00573
ChemSpider 3225 YesY
UNII RA33EAC7KY YesY
KEGG D02350 YesY
ChEBI CHEBI:5004 YesY
ChEMBL CHEMBL1297 YesY
Chemical data
Formula C15H14O3 
Mol. mass 242.26986 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.

Contents

Pharmacology

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Contraindications

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Drug Interactions

Aminoglycosides (eg, gentamicin): Plasma aminoglycoside levels may be elevated.
Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
Anticoagulants: Coadministration may prolong prothrombin time.
Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
Methotrexate: May increase methotrexate levels.
Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
SSRIs (eg, fluoxetine, citalopram): The risk of GI effects may be increased.

Laboratory Test Interactions

False elevation in free and total serum T 3 as measured by Amerlex-M kit.

Brand names

  • UK - Fenopron (Typharm Limited)

References

Fenoprofen info from Drugs.com

v · d · eAnti-inflammatory products (M01A)
Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)
v · d · eNon-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Celecoxib • Deracoxib‡ • Etoricoxib • Firocoxib‡ • Lumiracoxib† • Parecoxib • Rofecoxib† • Valdecoxib†
Sulfonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
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