Fluproquazone

drugbox
IUPAC_name = 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one

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CAS_number = 40507-23-1
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PubChem = 38503
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C=18 | H=17 | F=1 | N=2 | O=1
molecular_weight = 296.339 g/mol
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Fluproquazone (Tormosyl) is a quinazolinone derivative with potent analgesic [Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. "Arzneimittelforschung". 1981;31(5a):918-20.] [Wheatley D. Analgesic properties of fluproquazone. "Rheumatology and Rehabilitation". 1982 May;21(2):98-100.] and antipyretic [Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. "Arzneimittelforschung". 1981;31(5a):934-5.] effects and also anti-inflammatory action. It has been shown to be effective in a variety of animal species after both oral and parenteral administration, and has a duration of action of several hours. The compound is many times more potent than acetylsalicylic acid and clinically generally resembles ibuprofen and indoprofen in its pharmacological effects, but with significantly less ulcerogenic activity. [Gillberg R, Korsan-Bengtsen K, Magnusson B, Nyberg G. Gastrointestinal blood loss, gastroscopy and coagulation factors in normal volunteers during administration of acetylsalicylic acid and fluproquazone. "Scandinavian Journal of Rheumatology". 1981;10(4):342-6.] It is mainly used in the treatment of arthritis [Huskisson EC, Bryans R, Scott J. Fluproquazone for osteoarthritis. "Rheumatology and Rehabilitation". 1981 May;20(2):122-4.] and post-operative pain. [Haanaes HR, Benterud UJ, Skoglund LA. RF 46-790 versus paracetamol: effect on post-operative pain. "International Journal of Clinical Pharmacology, Therapy, and Toxicology". 1986 Nov;24(11):598-601.]

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