Cinchophen

Cinchophen

Systematic (IUPAC) name
2-phenylquinoline-4-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	132-60-5
ATC code	M04AC02
PubChem	CID 8593
ChemSpider	8274 Y
UNII	39Y533Z02M Y
KEGG	D07280 Y
ChEMBL	CHEMBL348000 Y
Chemical data
Formula	C16H11NO2
Mol. mass	249.264 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19) Y Key:YTRMTPPVNRALON-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Cinchophen (trade names Atophan, Quinophan, and Phenaquin) is an analgesic drug that was introduced in 1910 and frequently used to treat gout. This drug is still used, in combination with Prednisolone, by veterinarians to treat arthritis in animals.

Use of this drug in humans ceased in the 1930s due to the discovery that cinchophen can cause serious liver damage.^[1]

There is some evidence that it stimulates C-Fos.^[2]

References

1. ^ Cutrín Prieto C, Nieto Pol E, Batalla Eiras A, Casal Iglesias L, Pérez Becerra E, Lorenzo Zúñiga V (1991). "[Toxic hepatitis from cinchophen: report of 3 cases]" (in Spanish; Castilian). Medicina clínica 97 (3): 104–6. PMID 1679861. 
2. ^ Takayama K, Xiong Y, Miura M (May 1994). "Neuronal expression of Fos protein in the paraventricular nucleus of the hypothalamus after i.p. injection of ulcergenic cinchophen". Neurosci. Lett. 172 (1–2): 55–8. doi:10.1016/0304-3940(94)90661-0. PMID 7916144. http://linkinghub.elsevier.com/retrieve/pii/0304-3940(94)90661-0. 

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This analgesic-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Aromatic acids Analgesics Quinolines Musculoskeletal system drug stubs Analgesic stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Fintry Lambayeque Look at other dictionaries: cinchophen — noun An analgesic drug used to treat gout in animals (and, until the 1930s, in humans, when it was found to cause liver damage) …   Wiktionary cinchophen — An analgesic, antipyretic, and uricosuric agent that may produce liver damage and gastric lesions; used in experimental animals to produce gastric ulcer. * * * cin·cho·phen .fen, fən n a bitter white crystalline compoun …   Medical dictionary cinchophen — cin·cho·phen …   English syllables cinchophen — ˈ ̷ ̷ ̷ ̷ˌfen, fən noun ( s) Etymology: cinchoninic + phenyl : a bitter white crystalline compound C9H5N(C6H5)COOH made synthetically and used for treating gout and rheumatism but damaging to the liver; 2 phenyl cinchoninic acid …   Useful english dictionary АТХ код M04 — АТХ M «Препараты для лечения заболеваний костно мышечной системы» АТХ код M01 Противовоспалительные и противоревматические препараты АТХ код M02 Препараты для местного применения при болевом синдроме при заболеваниях костно мышечной системы АТХ… …   Википедия Gout — Podagra redirects here. For the moth genus, see Podagra (moth). Gout Classification and external resources Gout, a 1799 caricature by James Gillray …   Wikipedia Allopurinol — Not to be confused with Enalapril. Allopurinol Systematic (IUPAC) name …   Wikipedia Colchicine — Systematic (IUPAC) name N ​[(7S …   Wikipedia Hip dysplasia (canine) — Hip dysplasia is a disease that, in its more severe form, can eventually cause crippling lameness and painful arthritis of the joints. It is caused by a combination of genetic and environmental factors. It can be found in many animals and… …   Wikipedia ATC code M04 — A section of the Anatomical Therapeutic Chemical Classification System.M Musculo skeletal systemM04A Antigout preparationsM04AA Preparations inhibiting uric acid production:M04AA01 Allopurinol:M04AA02 Tisopurine:M04AA51 Allopurinol, combinations …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”