Dectaflur

Dectaflur
Dectaflur
Systematic (IUPAC) name
9-Octadeceylamine hydrofluoride
Clinical data
Pregnancy cat.  ?
Legal status OTC
Routes Topical (gel, solution)
Identifiers
CAS number 36505-83-6
ATC code None
PubChem CID 6436136
UNII Q3B1Y93C1S
Chemical data
Formula C18H38FN 
Mol. mass 287,50 g/mol
SMILES eMolecules & PubChem

Dectaflur (INN) is a fluoride-containing substance used for the prevention and treatment of dental caries, sensitive teeth, and the refluoridation of damaged tooth enamel, typically in combination with olaflur.[1]

Chemistry and mechanism of action

Dectaflur consists of oleyl amine (the amine corresponding to oleyl alcohol) and hydrofluoric acid. Oleyl amine with its long lipophilic hydrocarbon chain has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the top layers of the enamel, reaching a depth of only a few nanometers. The precise mechanism of action is unknown.[2]

Side effects

Like other fluorides, dectafur is toxic when overdosed over an extended period of time. Especially in children, before the development of the permanent teeth, overdosage can lead to dental fluorosis.[3]

References

  1. ^ Haberfeld, H, ed (2009) (in German). Austria-Codex (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 3-85200-196-X. 
  2. ^ Müller, F.; Zeitz, C.; Mantz, H.; Ehses, K. H.; Soldera, F.; Schmauch, J.; Hannig, M.; Hüfner, S. et al. (2010). "Elemental Depth Profiling of Fluoridated Hydroxyapatite: Saving Your Dentition by the Skin of Your Teeth?". Langmuir 26 (24): 18750–18759. doi:10.1021/la102325e. PMID 21090577.  edit
  3. ^ Alvarez, J. A.; Rezende, K. M.; Marocho, S. M.; Alves, F. B.; Celiberti, P.; Ciamponi, A. L. (2009). "Dental fluorosis: Exposure, prevention and management". Medicina oral, patologia oral y cirugia bucal 14 (2): E103–E107. PMID 19179949.  edit



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