Chlortetracycline

Chlortetracycline

Systematic (IUPAC) name
(4S,4aS,5aS,6S,12aS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydrotetracene-1,3,12(2H,4H,12aH)-trione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Routes	Oral, IV, topical
Pharmacokinetic data
Bioavailability	30%
Protein binding	50 to 55%
Metabolism	Hepatic (75%)
Half-life	5.6 to 9 hours
Excretion	Renal and biliary
Identifiers
CAS number	57-62-5 Y
ATC code	A01AB21 D06AA02 J01AA03 S01AA02 QJ51AA03
ChemSpider	10469370 Y
UNII	WCK1KIQ23Q Y
KEGG	D07689 Y
ChEMBL	CHEMBL456066 N
Chemical data
Formula	C22H23ClN2O8
Mol. mass	478.88 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1 Y Key:CYDMQBQPVICBEU-XRNKAMNCSA-N Y
N(what is this?)  (verify)

Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be identified. It was discovered in 1945 by Dr. Benjamin Duggar working at Lederle Laboratories. Duggar identified the antibiotic as the product of a actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.^[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.

In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.^[2]

References

1. ^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
2. ^ Merck Veterinary Manual. http://merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/30200.htm. 

This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it.v ·

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.v ·

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Tetracycline antibiotics Organochlorides Antibiotic stubs Gastrointestinal system drug stubs Dermatologic drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Bands of America Chatham, Chicago Look at other dictionaries: chlortetracycline — n. a yellow crystalline antibacterial antibiotic used to treat certain bacterial and rickettsial diseases. {Aureomycin} is one common trademark for chlortetracycline. Syn: Aureomycin. [WordNet 1.5] …   The Collaborative International Dictionary of English Chlortetracycline — См. Хлортетрациклин (Источник: «Словарь терминов микробиологии») …   Словарь микробиологии chlortétracycline — ● chlortétracycline nom féminin Antibiotique dérivé de la tétracycline, élaboré par Streptomyces aureolaciens, à large spectre d activité …   Encyclopédie Universelle chlortetracycline — ☆ chlortetracycline [klôrte΄trə sī′klin, klôr te΄trə sī′klīn΄ ] n. [ CHLOR(O) + TETRACYCLINE] a yellow antibiotic, C22H23ClN2O8, isolated from a microorganism ( Streptomyces aureofaciens): it is used against a wide variety of bacterial and… …   English World dictionary chlortetracycline — Aureomycin Aureomycin n. 1. [a trademark.] a yellow crystalline antibiotic (generic name {chlortetracycline}) used to treat certain bacterial and rickettsial diseases. Syn: chlortetracycline. [WordNet 1.5] || …   The Collaborative International Dictionary of English chlortetracycline hydrochloride — [USP] the monohydrochloride salt of chlortetracycline, a broad spectrum antibiotic used as an antibacterial and antiprotozoal; administered orally or intravenously, or applied topically to the skin or conjunctiva …   Medical dictionary chlortetracycline — noun Date: 1953 a yellow crystalline broad spectrum antibiotic C22H23ClN2O8 that is produced by a soil actinomycete (Streptomyces aureofaciens) and is sometimes used in animal feeds to stimulate growth …   New Collegiate Dictionary Chlortetracycline — …   Википедия chlortetracycline — /klawr te treuh suy klin, kleen, klohr /, n. Pharm. a yellow, crystalline, antibiotic powder, C22H23N2O8Cl, biosynthesized by Streptomyces aureofaciens, used in the treatment of infections. [1950 55; CHLOR 2 + TETRACYCLINE] * * * …   Universalium chlortetracycline — noun A particular tetracycline antibiotic. Syn: aureomycin …   Wiktionary 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link https://en-academic.com/dic.nsf/enwiki/699229 Do a right-click on the link above and select “Copy Link”