Spectinomycin

Spectinomycin

drugbox
IUPAC_name = (2"R",4a"R",5a"R",6"S",7"S",8"R",9"S",9a"R",10a"S")-
4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)
decahydro-4"H"-pyrano [2,3-b] [1,4] benzodioxin-4-one


CAS_number = 1695-77-8
ATC_prefix = J01
ATC_suffix = XX04
ATC_supplemental =
PubChem = 15541
DrugBank = APRD01232
C = 14 | H = 24 | N = 2 | O = 7
molecular_weight = 332.35 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_US = B
legal_status = not available in US
routes_of_administration =

Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol antibiotic produced by the bacterium "Streptomyces spectabilis".

There was a disruption in the supply in 2001.cite journal |author= |title=From the Centers for Disease Control and Prevention. Update on spectinomycin availability in the United States |journal=JAMA |volume=286 |issue=11 |pages=1308–9 |year=2001 |month=September |pmid=11575327 |doi= |url=http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=11575327]

Mechanism

It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis.

One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida.cite journal |author=Kehrenberg C, Schwarz S |title=Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida |journal=Antimicrob. Agents Chemother. |volume=51 |issue=6 |pages=2244–6 |year=2007 |month=June |pmid=17371823 |pmc=1891365 |doi=10.1128/AAC.00229-07 |url=]

Uses

It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins.

ide effects

Side effects include itching, chills, stomach-ache, and red rash.

References


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Look at other dictionaries:

  • spectinomycin — [spek΄tə nō mī′sin] n. an antibiotic, C14H24N2O7, made synthetically or obtained from an actinomycete ( Streptomyces spectabilis) and used esp. in treating cases of gonorrhea that are resistant to penicillin …   English World dictionary

  • Spectinomycin — Strukturformel Allgemeines Name Spectinomycin Andere Namen …   Deutsch Wikipedia

  • spectinomycin hydrochloride — An antibiotic antibacterial agent. * * * [USP] a salt of spectinomycin used in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female …   Medical dictionary

  • spectinomycin — noun Etymology: spect (from New Latin spectabilis, specific epithet of Streptomyces spectabilis) + actinomycin Date: 1964 a white crystalline broad spectrum antibiotic C14H24N2O7 produced by a bacterium (Streptomyces spectabilis) that is used… …   New Collegiate Dictionary

  • spectinomycin — Aminocyclitol antibiotic: acts on ribosome, but is bacteriostatic rather than bactericidal …   Dictionary of molecular biology

  • spectinomycin — /spek teuh noh muy sin/, n. Pharm. an antibiotic drug, C14H24N2O7, produced by the actinomycete Streptomyces spectabilis, used in the treatment of susceptible gonorrhea. [1960 65; b. NL spectabilis a specific epithet (lit., visible; see SPECTACLE …   Universalium

  • spectinomycin — noun An aminocyclitol antibiotic produced by the bacterium Streptomyces spectabilis …   Wiktionary

  • spectinomycin — spec·ti·no·my·cin .spek tə nō mīs ən n a white crystalline broad spectrum antibiotic derived from a bacterium of the genus Streptomyces (S. spectabilis) that is used clinically esp. in the form of its hydrated dihydrochloride C14H24N2O7·2HCl·5H2O …   Medical dictionary

  • spectinomycin — spec·ti·no·my·cin …   English syllables

  • spectinomycin — noun an antibiotic used to treat gonorrhea • Hypernyms: ↑antibiotic, ↑antibiotic drug …   Useful english dictionary

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