Clomocycline

Clomocycline: Clomocycline

Systematic (IUPAC) name

(2Z,4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(hydroxymethyl)amino]methylidene}-6-methyl-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 1181-54-0

ATC code J01AA11

PubChem CID 5464321

DrugBank DB00453

ChemSpider 16735748^Y

UNII YP0241BU76^Y

KEGG D06885^Y

Synonyms (2Z,4S,4aS,5aS,6S,12aS)-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-2-[hydroxy-(hydroxymethylamino)methylidene]-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

Chemical data

Formula C₂₃H₂₅Cl N₂O₉

Mol. mass 508.905 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)/t8?,9-,16-,22-,23-/m0/s1^Y
Key:GJGDLRSSCNAKGL-BJNNJSPUSA-N^Y

Y(what is this?) (verify)

Clomocycline is a tetracycline antibiotic.

v · d · eAntibacterials: protein synthesis inhibitors (J01A, J01B, J01F, J01G, QJ01XQ)

30S

Aminoglycosides
(initiation inhibitors)

-mycin (Streptomyces)

Streptomycin^#

Neomycin^# (Framycetin, Paromomycin, Ribostamycin)

Kanamycin^# (Amikacin, Arbekacin, Bekanamycin, Dibekacin, Tobramycin)

Spectinomycin^# • Hygromycin B
Paromomycin

-micin (Micromonospora)

Gentamicin^# (Netilmicin, Sisomicin, Isepamicin)
Verdamicin
Astromicin

Tetracycline antibiotics
(tRNA binding)

Tetracyclines

Doxycycline^# •Chlortetracycline • Clomocycline • Demeclocycline • Lymecycline • Meclocycline • Metacycline • Minocycline • Oxytetracycline • Penimepicycline • Rolitetracycline • Tetracycline

Glycylcyclines

Tigecycline

50S

Oxazolidinone
(initiation inhibitors)

Linezolid • Torezolid • Eperezolid • Posizolid • Radezolid

Peptidyl transferase

Amphenicols

Chloramphenicol^# • Azidamfenicol • Thiamphenicol • Florfenicol

Pleuromutilins

Retapamulin • Tiamulin • Valnemulin

MLS (transpeptidation/translocation)

Macrolides

Erythromycin^# • Azithromycin^# • Spiramycin • Midecamycin • Oleandomycin • Roxithromycin • Josamycin • Troleandomycin • Clarithromycin • Miocamycin • Rokitamycin • Dirithromycin • Flurithromycin • Ketolide (Telithromycin, Cethromycin, Solithromycin)

Lincosamides

Clindamycin^# • Lincomycin

Streptogramins

Pristinamycin • Quinupristin/dalfopristin • Virginiamycin

EF-G

Steroid antibacterials

Fusidic acid

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)

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Clomocycline

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Systematic (IUPAC) name
(2Z,4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(hydroxymethyl)amino]methylidene}-6-methyl-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1181-54-0
ATC code	J01AA11
PubChem	CID 5464321
DrugBank	DB00453
ChemSpider	16735748^Y
UNII	YP0241BU76^Y
KEGG	D06885^Y
Synonyms	(2Z,4S,4aS,5aS,6S,12aS)-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-2-[hydroxy-(hydroxymethylamino)methylidene]-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
Chemical data
Formula	C₂₃H₂₅Cl N₂O₉
Mol. mass	508.905 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-28,30-31,34-35H,6-7H2,1-3H3,(H,25,33)/t8?,9-,16-,22-,23-/m0/s1^Y Key:GJGDLRSSCNAKGL-BJNNJSPUSA-N^Y
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Clomocycline

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