Systematic (IUPAC) name
Clinical data
AHFS/ monograph
Pregnancy cat.  ?
Legal status  ?
Routes Topical
CAS number 138-39-6 YesY
ATC code D06BA03
PubChem CID 3998
ChemSpider 3858 YesY
UNII 58447S8P4L N
KEGG D02351 YesY
Chemical data
Formula C7H10N2O2S 
Mol. mass 186.233 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide.



It is used to treat severe burns.[1][2]

Mafenide (Sulfamylon) can interfere with the kidney's role in hydrogen ion excretion, resulting in metabolic acidosis.
Mafenide is a topical sulfonamide used as adjunctive therapy of second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms including Pseudomonas aeruginosa. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could result in metabolic acidosis. This drug was approved by the FDA in 1948. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.[3]

Mechanism of Action

Mechanism of Action: Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.
Contraindications/Precautions:Sulfonamide hypersensitivity; renal impairment.

Adverse Reactions

Superinfection, pain or burning upon application, rash, pruritus, tachypnea, hyperventilation, metabolic acidosis.

Drug interaction

Drug Interactions: No significant interactions


For use adjunctive therapy of second- and third-degree burns to prevent infection: Topical dosage: Adults and children: Apply topically to a thickness of approximately 1.6 mm, to cleaned and debrided wound once or twice per day with a sterile gloved hand. Burned area should be covered with cream at all times.

See also


  1. ^ Siuda J. F., Cihonski C. D. (1972). "New compounds: carbamate derivatives of mafenide (homosulfanilamide)". J. Pharm. Sci. 61 (11): 1856–1857. doi:10.1002/jps.2600611143. PMID 4652670. 
  2. ^ Haynes B. (1971). "Mafenide acetate in Burn Treatment". New England J. Medic. 284 (23): 1324. doi:10.1056/NEJM197106102842310. PMID 5576444. 
  3. ^ Haik J, Ashkenazy O, Sinai S, et al. (November 2005). "Burn care standards in Israel: lack of consensus". Burns 31 (7): 845–9. doi:10.1016/j.burns.2005.04.012. PMID 15967581. 

External links