Mafenide

Mafenide

Systematic (IUPAC) name
4-(aminomethyl)benzenesulfonamide
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	?
Routes	Topical
Identifiers
CAS number	138-39-6 Y
ATC code	D06BA03
PubChem	CID 3998
ChemSpider	3858 Y
UNII	58447S8P4L N
KEGG	D02351 Y
ChEMBL	CHEMBL419 Y
Chemical data
Formula	C7H10N2O2S
Mol. mass	186.233 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) Y Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide.

Uses

It is used to treat severe burns.^[1][2]

Mafenide (Sulfamylon) can interfere with the kidney's role in hydrogen ion excretion, resulting in metabolic acidosis.
Mafenide is a topical sulfonamide used as adjunctive therapy of second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms including Pseudomonas aeruginosa. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could result in metabolic acidosis. This drug was approved by the FDA in 1948. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.^[3]

Mechanism of Action

Mechanism of Action: Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.
Contraindications/Precautions:Sulfonamide hypersensitivity; renal impairment.

Adverse Reactions

Superinfection, pain or burning upon application, rash, pruritus, tachypnea, hyperventilation, metabolic acidosis.

Drug interaction

Drug Interactions: No significant interactions

Dosage:

For use adjunctive therapy of second- and third-degree burns to prevent infection: Topical dosage: Adults and children: Apply topically to a thickness of approximately 1.6 mm, to cleaned and debrided wound once or twice per day with a sterile gloved hand. Burned area should be covered with cream at all times.

See also

• carbonic anhydrase

References

1. ^ Siuda J. F., Cihonski C. D. (1972). "New compounds: carbamate derivatives of mafenide (homosulfanilamide)". J. Pharm. Sci. 61 (11): 1856–1857. doi:10.1002/jps.2600611143. PMID 4652670. 
2. ^ Haynes B. (1971). "Mafenide acetate in Burn Treatment". New England J. Medic. 284 (23): 1324. doi:10.1056/NEJM197106102842310. PMID 5576444. 
3. ^ Haik J, Ashkenazy O, Sinai S, et al. (November 2005). "Burn care standards in Israel: lack of consensus". Burns 31 (7): 845–9. doi:10.1016/j.burns.2005.04.012. PMID 15967581. http://linkinghub.elsevier.com/retrieve/pii/S0305-4179(05)00130-0. 

External links

• Mafenide information on RxList

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Carbonic anhydrase inhibitors Sulfonamide antibiotics Antibiotic stubs Antihypertensive agent stubs Dermatologic drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Malaipaṭukaṭām Prospect Highway, Sydney Look at other dictionaries: mafenide acetate — [USP] the monoacetate salt of mafenide, having the same antibacterial activity as the base; used as a topical antiinfective for adjunctive therapy of patients with second and third degree burns …   Medical dictionary mafenide hydrochloride — the hydrochloride salt of mafenide, having antibacterial activity similar to that of the acetate salt; used as a topical antiinfective …   Medical dictionary mafenide — /meuh fen uyd/, Pharm. an antibacterial substance, C7H10N2O2S, prepared in cream form and used topically, along with other treatments, on second to third degree burns to reduce bacterial growth. [maf (perh. reversed letters from SULFONAMIDE) +… …   Universalium mafenide — noun A particular kind of sulfonamide that is used to help treat severe burns …   Wiktionary mafenide — A topical antibacterial agent active against anaerobic pathogens. M. acetate is the preferred salt for ointment; m. hydrochloride is the preferred salt for solution. SYN: 4 homosulfanilamide. * * * maf·e·nide …   Medical dictionary mafenide — /meuh fen uyd/, Pharm. an antibacterial substance, C7H10N2O2S, prepared in cream form and used topically, along with other treatments, on second to third degree burns to reduce bacterial growth. [maf (perh. reversed letters from SULFONAMIDE) +… …   Useful english dictionary List of antibiotics — Following is the list of antibiotics, sorted by class. The highest division is between bactericidal antibiotics and bacteriostatic antibiotics. Bactericidals kill bacteria directly where bacteriostatics prevent them from dividing. However, these… …   Wikipedia Sulfamylon — Sul·fa·my·lon .səl fə mī .län trademark used for a preparation of the acetate of mafenide * * * Sul·fa·my·lon (sul″fə miґlon) trademark for preparations of mafenide …   Medical dictionary Chloramphenicol — Systematic (IUPAC) name …   Wikipedia Tetracycline — This article is about the specific antibiotic called tetracycline. For other uses, see tetracycline antibiotics. Tetracycline Systematic (IUPAC) name (4S,6S,12aS) 4 (dimethylamino) 1,4,4a,5,5a,6,11,12a o …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”