Sitafloxacin

Sitafloxacin
Sitafloxacin
Systematic (IUPAC) name
7- [(4S)- 4-amino- 6-azaspiro [2.4] heptan- 6-yl]- 8-chloro- 6-fluoro- 1- [(2S)- 2-fluorocyclopropyl]- 4-oxoquinoline- 3-carboxylic acid
Clinical data
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 127254-12-0 YesY
ATC code J01MA21
PubChem CID 461399
ChemSpider 405945 YesY
UNII 3GJC60U4Q8 N
ChEMBL CHEMBL108821 N
Chemical data
Formula C19H18ClF2N3O3 
Mol. mass 409.81
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Sitafloxacin (INN; also called DU-6859a) is a fluoroquinolone antibiotic[1] that shows promise in the treatment of Buruli ulcer. The molecule was identified by Daiichi Sankyo Co., which brought ofloxacin and levofloxacin to the market. Sitafloxacin is currently marketed in Japan by Daiichi Sankyo under the tradename Gracevit.

See also

  • Fluoroquinolone toxicity
  • Fluoroquinolone

References

  1. ^ Anderson, DL. (Jul 2008). "Sitafloxacin hydrate for bacterial infections.". Drugs Today (Barc) 44 (7): 489–501. doi:10.1358/dot.2008.44.7.1219561. PMID 18806900. 
v · d · eAntibacterials: nucleic acid inhibitors (J01E, J01M)
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)
2,4-Diaminopyrimidine (Trimethoprim#, Brodimoprim, Tetroxoprim, Iclaprim†)
Sulfonamides
(DHPS inhibitor)
Other/ungrouped
Combinations
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)
1st g.
2nd g.
3rd g.
4th g.
Besifloxacin • Clinafloxacin† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin‡ • Sitafloxacin • Trovafloxacin‡/Alatrofloxacin‡ • Prulifloxacin
Vet.
Related (DG)
Anaerobic DNA
inhibitors
Nitro- imidazole derivatives
Nitrofuran derivatives
RNA synthesis

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)
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